| http://purl.uniprot.org/citations/20534810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20534810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20534810 | http://www.w3.org/2000/01/rdf-schema#comment | "DYF-1 is a highly conserved protein essential for ciliogenesis in several model organisms. In Caenorhabditis elegans, DYF-1 serves as an essential activator for an anterograde motor OSM-3 of intraflagellar transport (IFT), the ciliogenesis-required motility that mediates the transport of flagellar precursors and removal of turnover products. In zebrafish and Tetrahymena DYF-1 influences the cilia tubulin posttranslational modification and may have more ubiquitous function in ciliogenesis than OSM-3. Here we address how DYF-1 biochemically interacts with the IFT machinery by using the model organism Chlamydomonas reinhardtii, in which the anterograde IFT does not depend on OSM-3. Our results show that this protein is a stoichiometric component of the IFT particle complex B and interacts directly with complex B subunit IFT46. In concurrence with the established IFT protein nomenclature, DYF-1 is also named IFT70 after the apparent size of the protein. IFT70/CrDYF-1 is essential for the function of IFT in building the flagellum because the flagella of IFT70/CrDYF-1-depleted cells were greatly shortened. Together, these results demonstrate that IFT70/CrDYF-1 is a canonical subunit of IFT particle complex B and strongly support the hypothesis that the IFT machinery has species- and tissue-specific variations with functional ramifications."xsd:string |
| http://purl.uniprot.org/citations/20534810 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e10-03-0191"xsd:string |
| http://purl.uniprot.org/citations/20534810 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e10-03-0191"xsd:string |
| http://purl.uniprot.org/citations/20534810 | http://purl.uniprot.org/core/author | "Qin H."xsd:string |
| http://purl.uniprot.org/citations/20534810 | http://purl.uniprot.org/core/author | "Qin H."xsd:string |
| http://purl.uniprot.org/citations/20534810 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/20534810 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/20534810 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/20534810 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/20534810 | http://purl.uniprot.org/core/author | "Behal R.H."xsd:string |
| http://purl.uniprot.org/citations/20534810 | http://purl.uniprot.org/core/author | "Behal R.H."xsd:string |
| http://purl.uniprot.org/citations/20534810 | http://purl.uniprot.org/core/author | "Geimer S."xsd:string |
| http://purl.uniprot.org/citations/20534810 | http://purl.uniprot.org/core/author | "Geimer S."xsd:string |
| http://purl.uniprot.org/citations/20534810 | http://purl.uniprot.org/core/author | "Cole D.G."xsd:string |
| http://purl.uniprot.org/citations/20534810 | http://purl.uniprot.org/core/author | "Cole D.G."xsd:string |
| http://purl.uniprot.org/citations/20534810 | http://purl.uniprot.org/core/author | "Fan Z.C."xsd:string |
| http://purl.uniprot.org/citations/20534810 | http://purl.uniprot.org/core/author | "Fan Z.C."xsd:string |
| http://purl.uniprot.org/citations/20534810 | http://purl.uniprot.org/core/author | "Williamson S.M."xsd:string |
| http://purl.uniprot.org/citations/20534810 | http://purl.uniprot.org/core/author | "Williamson S.M."xsd:string |
| http://purl.uniprot.org/citations/20534810 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20534810 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20534810 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/20534810 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |