| http://purl.uniprot.org/citations/20535151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20535151 | http://www.w3.org/2000/01/rdf-schema#comment | "Over expression of BAALC (brain and acute leukemia, cytoplasmic) predicts an inferior outcome in acute myeloid leukemia (AML) and acute lymphoblastic leukemia patients. To identify BAALC-associated genes that give insights into its functional role in chemotherapy resistance, gene expression signatures differentiating high from low BAALC expressers were generated from normal CD34(+) progenitors, T-acute lymphoblastic leukemia (T-ALL) and AML samples. The insulin-like growth factor binding protein 7 (IGFBP7) was one of the four genes (CD34, CD133, natriuretic peptide receptor C (NPR3), IGFBP7) coexpressed with BAALC and common to the three entities. In T-ALL, high IGFBP7-expression was associated with an immature phenotype of early T-ALL (P<0.001), expression of CD34 (P<0.001) and CD33 (P<0.001). Moreover, high IGFBP7-expression predicted primary therapy resistance (P=0.03) and inferior survival in T-ALL (P=0.03). In vitro studies revealed that IGFBP7 protein significantly inhibited the proliferation of leukemia cell lines (Jurkat cells: 42% reduction, P=0.002; KG1a cells: 65% reduction, P<0.001). In conclusion, IGFBP7 was identified as a BAALC coexpressed gene. Furthermore, high IGFBP7 was associated with stem cell features and treatment failure in T-ALL. In contrast to BAALC, which likely represents only a surrogate marker of treatment failure in acute leukemia, IGFBP7 regulates the proliferation of leukemic cells and might be involved in chemotherapy resistance."xsd:string |
| http://purl.uniprot.org/citations/20535151 | http://purl.org/dc/terms/identifier | "doi:10.1038/leu.2010.130"xsd:string |
| http://purl.uniprot.org/citations/20535151 | http://purl.uniprot.org/core/author | "Schwartz S."xsd:string |
| http://purl.uniprot.org/citations/20535151 | http://purl.uniprot.org/core/author | "Heesch S."xsd:string |
| http://purl.uniprot.org/citations/20535151 | http://purl.uniprot.org/core/author | "Neumann M."xsd:string |
| http://purl.uniprot.org/citations/20535151 | http://purl.uniprot.org/core/author | "Hofmann W.K."xsd:string |
| http://purl.uniprot.org/citations/20535151 | http://purl.uniprot.org/core/author | "Hoelzer D."xsd:string |
| http://purl.uniprot.org/citations/20535151 | http://purl.uniprot.org/core/author | "Thiel E."xsd:string |
| http://purl.uniprot.org/citations/20535151 | http://purl.uniprot.org/core/author | "Haferlach T."xsd:string |
| http://purl.uniprot.org/citations/20535151 | http://purl.uniprot.org/core/author | "Goekbuget N."xsd:string |
| http://purl.uniprot.org/citations/20535151 | http://purl.uniprot.org/core/author | "Stroux A."xsd:string |
| http://purl.uniprot.org/citations/20535151 | http://purl.uniprot.org/core/author | "Baldus C.D."xsd:string |
| http://purl.uniprot.org/citations/20535151 | http://purl.uniprot.org/core/author | "Schlee C."xsd:string |
| http://purl.uniprot.org/citations/20535151 | http://purl.uniprot.org/core/author | "Kuhnl A."xsd:string |
| http://purl.uniprot.org/citations/20535151 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20535151 | http://purl.uniprot.org/core/name | "Leukemia"xsd:string |
| http://purl.uniprot.org/citations/20535151 | http://purl.uniprot.org/core/pages | "1429-1436"xsd:string |
| http://purl.uniprot.org/citations/20535151 | http://purl.uniprot.org/core/title | "BAALC-associated gene expression profiles define IGFBP7 as a novel molecular marker in acute leukemia."xsd:string |
| http://purl.uniprot.org/citations/20535151 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/20535151 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20535151 |
| http://purl.uniprot.org/citations/20535151 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20535151 |
| http://purl.uniprot.org/uniprot/#_Q16270-mappedCitation-20535151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20535151 |
| http://purl.uniprot.org/uniprot/#_Q8WXS3-mappedCitation-20535151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20535151 |
| http://purl.uniprot.org/uniprot/Q8WXS3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20535151 |