| http://purl.uniprot.org/citations/20536348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20536348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20536348 | http://www.w3.org/2000/01/rdf-schema#comment | "The expression of p185(Bcr-Abl) in Ba/F3 cells inhibits the chemotactic response of these cells to SDF1alpha. A mutant p185(Bcr-Abl) with deletion of amino acids from 176 to 426 (p185(Delta176-426)) is deficient in suppressing SDF1alpha-stimulated chemotaxis. Comparison of the gene expression profiles among parental Ba/F3 cells and cells transformed by p185(Bcr-Abl) and p185(Delta176-426) reveals that class II phosphoinositide 3-kinase gamma (PI3KC2gamma) expression is markedly down-regulated by p185(Bcr-Abl) but not p185(Delta176-426). Furthermore, knockdown of PI3KC2gamma expression in p185(Delta176-426) cells is sufficient to suppress SDF1alpha-stimulated chemotaxis and to promote infiltration of these cells into the liver. Together, these studies suggest that inhibition of PI3KC2gamma expression may represent a mechanism by which Bcr-Abl suppresses SDF1alpha-induced chemotaxis and induces abnormal homing of leukemic cells."xsd:string |
| http://purl.uniprot.org/citations/20536348 | http://purl.org/dc/terms/identifier | "doi:10.3109/10428191003754624"xsd:string |
| http://purl.uniprot.org/citations/20536348 | http://purl.org/dc/terms/identifier | "doi:10.3109/10428191003754624"xsd:string |
| http://purl.uniprot.org/citations/20536348 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/20536348 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/20536348 | http://purl.uniprot.org/core/author | "Tao Y."xsd:string |
| http://purl.uniprot.org/citations/20536348 | http://purl.uniprot.org/core/author | "Tao Y."xsd:string |
| http://purl.uniprot.org/citations/20536348 | http://purl.uniprot.org/core/author | "Tang H."xsd:string |
| http://purl.uniprot.org/citations/20536348 | http://purl.uniprot.org/core/author | "Tang H."xsd:string |
| http://purl.uniprot.org/citations/20536348 | http://purl.uniprot.org/core/author | "Yu W."xsd:string |
| http://purl.uniprot.org/citations/20536348 | http://purl.uniprot.org/core/author | "Yu W."xsd:string |
| http://purl.uniprot.org/citations/20536348 | http://purl.uniprot.org/core/author | "Dai Z."xsd:string |
| http://purl.uniprot.org/citations/20536348 | http://purl.uniprot.org/core/author | "Dai Z."xsd:string |
| http://purl.uniprot.org/citations/20536348 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20536348 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20536348 | http://purl.uniprot.org/core/name | "Leuk. Lymphoma"xsd:string |
| http://purl.uniprot.org/citations/20536348 | http://purl.uniprot.org/core/name | "Leuk. Lymphoma"xsd:string |
| http://purl.uniprot.org/citations/20536348 | http://purl.uniprot.org/core/pages | "1098-1107"xsd:string |
| http://purl.uniprot.org/citations/20536348 | http://purl.uniprot.org/core/pages | "1098-1107"xsd:string |
| http://purl.uniprot.org/citations/20536348 | http://purl.uniprot.org/core/title | "Inhibition of class II phosphoinositide 3-kinase gamma expression by p185(Bcr-Abl) contributes to impaired chemotaxis and aberrant homing of leukemic cells."xsd:string |
| http://purl.uniprot.org/citations/20536348 | http://purl.uniprot.org/core/title | "Inhibition of class II phosphoinositide 3-kinase gamma expression by p185(Bcr-Abl) contributes to impaired chemotaxis and aberrant homing of leukemic cells."xsd:string |
| http://purl.uniprot.org/citations/20536348 | http://purl.uniprot.org/core/volume | "51"xsd:string |
| http://purl.uniprot.org/citations/20536348 | http://purl.uniprot.org/core/volume | "51"xsd:string |