| http://purl.uniprot.org/citations/20538003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20538003 | http://www.w3.org/2000/01/rdf-schema#comment | "The transmembrane glycoprotein extracellular matrix metalloproteinase inducer (EMMPRIN), and the pleiotropic proinflammatory cytokine interleukin (IL)-18, play critical roles in myocardial remodeling, by inducing matrix degrading metalloproteinases (MMPs). Previously we showed that IL-18 induces EMMPRIN expression in cardiomyocytes via MyD88/IRAK4/TRAF6/JNK-dependent Sp1 activation. Here in reciprocal studies we demonstrate that EMMPRIN is a potent inducer of IL-18 transcription, protein expression and protein secretion in primary mouse cardiomyocytes. We show for the first time that EMMPRIN stimulates the activation of NF-kappaB, AP-1, CREB, and ATF-2 in cardiomyocytes, and induces IL-18 expression via Rac1-dependent PI3K/Akt/IKK/NF-kappaB and MKK7/JNK/AP-1 signaling. Moreover, EMMPRIN induces robust time-dependent induction of various MMP mRNAs. EMMPRIN also induces the mRNA of TIMPs 1 and 3, but in a delayed fashion. These results suggest that IL-18-induced EMMPRIN expression may favor net MMP expression and ECM destruction, and thus identify both as potential therapeutic targets in countering adverse myocardial remodeling."xsd:string |
| http://purl.uniprot.org/citations/20538003 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yjmcc.2010.05.007"xsd:string |
| http://purl.uniprot.org/citations/20538003 | http://purl.uniprot.org/core/author | "Valente A.J."xsd:string |
| http://purl.uniprot.org/citations/20538003 | http://purl.uniprot.org/core/author | "Chandrasekar B."xsd:string |
| http://purl.uniprot.org/citations/20538003 | http://purl.uniprot.org/core/author | "Delafontaine P."xsd:string |
| http://purl.uniprot.org/citations/20538003 | http://purl.uniprot.org/core/author | "Prabhu S.D."xsd:string |
| http://purl.uniprot.org/citations/20538003 | http://purl.uniprot.org/core/author | "Venkatesan B."xsd:string |
| http://purl.uniprot.org/citations/20538003 | http://purl.uniprot.org/core/author | "Shanmugam P."xsd:string |
| http://purl.uniprot.org/citations/20538003 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20538003 | http://purl.uniprot.org/core/name | "J Mol Cell Cardiol"xsd:string |
| http://purl.uniprot.org/citations/20538003 | http://purl.uniprot.org/core/pages | "655-663"xsd:string |
| http://purl.uniprot.org/citations/20538003 | http://purl.uniprot.org/core/title | "EMMPRIN activates multiple transcription factors in cardiomyocytes, and induces interleukin-18 expression via Rac1-dependent PI3K/Akt/IKK/NF-kappaB andMKK7/JNK/AP-1 signaling."xsd:string |
| http://purl.uniprot.org/citations/20538003 | http://purl.uniprot.org/core/volume | "49"xsd:string |
| http://purl.uniprot.org/citations/20538003 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20538003 |
| http://purl.uniprot.org/citations/20538003 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20538003 |
| http://purl.uniprot.org/uniprot/#_A0PJ18-mappedCitation-20538003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20538003 |
| http://purl.uniprot.org/uniprot/#_P70380-mappedCitation-20538003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20538003 |
| http://purl.uniprot.org/uniprot/#_P18572-mappedCitation-20538003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20538003 |
| http://purl.uniprot.org/uniprot/#_O55107-mappedCitation-20538003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20538003 |
| http://purl.uniprot.org/uniprot/#_O55108-mappedCitation-20538003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20538003 |
| http://purl.uniprot.org/uniprot/#_K3W4Q8-mappedCitation-20538003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20538003 |
| http://purl.uniprot.org/uniprot/#_Q8BPG5-mappedCitation-20538003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20538003 |
| http://purl.uniprot.org/uniprot/#_K7Q7T7-mappedCitation-20538003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20538003 |
| http://purl.uniprot.org/uniprot/#_Q2PMY2-mappedCitation-20538003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20538003 |