| http://purl.uniprot.org/citations/20538758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20538758 | http://www.w3.org/2000/01/rdf-schema#comment | "The innate immune system is crucial for host defense and immunosurveillance against pathogens and tumor cells. IL-15 is a pleiotropic cytokine with important effects on cells of the innate and adaptive immune systems. The NK cell- and CD8(+) T cell-mediated functions of IL-15 against tumor cells have been well documented. However, it has not been established whether IL-15 has innate anti-tumor functions independent of these cells. Here, we explored the innate anti-tumor potential of IL-15 using a B16F10 melanoma tumor model. IL-15tg mice exhibited significantly more resistance to tumor growth and metastasis compared to B6 mice, and to IL-15(-/-) mice, which exhibited increased susceptibility to B16F10 challenge. In vivo depletion of NK cells and CD8(+) T cells abrogated the innate resistance to B16F10 cells in B6 but not in IL-15tg mice. In addition, lung macrophages from IL-15tg mice produced significantly higher levels of NO and IL-12 compared with macrophages from B6 or IL-15(-/-) mice. To examine whether IL-15 has innate anti-tumor activity independent of NK cells and CD8(+) T cells, we developed Ad-Op-hIL-15; this resulted in significantly higher levels of biologically active hIL-15. Delivery of Ad-Op-hIL-15 into RAG-2(-/-)/gamma(c)(-/-) mice significantly suppressed tumor burden in the lungs compared with the control adenovirus vector. Our results show that IL-15 can have innate anti-tumor activity independent of NK cells and CD8(+) T cells and the common gamma(c)R."xsd:string |
| http://purl.uniprot.org/citations/20538758 | http://purl.org/dc/terms/identifier | "doi:10.1189/jlb.0909648"xsd:string |
| http://purl.uniprot.org/citations/20538758 | http://purl.uniprot.org/core/author | "Davies E."xsd:string |
| http://purl.uniprot.org/citations/20538758 | http://purl.uniprot.org/core/author | "Reid S."xsd:string |
| http://purl.uniprot.org/citations/20538758 | http://purl.uniprot.org/core/author | "Ashkar A.A."xsd:string |
| http://purl.uniprot.org/citations/20538758 | http://purl.uniprot.org/core/author | "Medina M.F."xsd:string |
| http://purl.uniprot.org/citations/20538758 | http://purl.uniprot.org/core/author | "Lichty B."xsd:string |
| http://purl.uniprot.org/citations/20538758 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20538758 | http://purl.uniprot.org/core/name | "J Leukoc Biol"xsd:string |
| http://purl.uniprot.org/citations/20538758 | http://purl.uniprot.org/core/pages | "529-536"xsd:string |
| http://purl.uniprot.org/citations/20538758 | http://purl.uniprot.org/core/title | "IL-15 has innate anti-tumor activity independent of NK and CD8 T cells."xsd:string |
| http://purl.uniprot.org/citations/20538758 | http://purl.uniprot.org/core/volume | "88"xsd:string |
| http://purl.uniprot.org/citations/20538758 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20538758 |
| http://purl.uniprot.org/citations/20538758 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20538758 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQZ2-mappedCitation-20538758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20538758 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQZ8-mappedCitation-20538758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20538758 |
| http://purl.uniprot.org/uniprot/#_B0QZX1-mappedCitation-20538758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20538758 |
| http://purl.uniprot.org/uniprot/#_P34902-mappedCitation-20538758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20538758 |
| http://purl.uniprot.org/uniprot/#_B7ZMX3-mappedCitation-20538758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20538758 |
| http://purl.uniprot.org/uniprot/#_Q1AHQ6-mappedCitation-20538758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20538758 |
| http://purl.uniprot.org/uniprot/#_Q1AHQ7-mappedCitation-20538758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20538758 |
| http://purl.uniprot.org/uniprot/#_Q8CD87-mappedCitation-20538758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20538758 |
| http://purl.uniprot.org/uniprot/#_P21784-mappedCitation-20538758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20538758 |
| http://purl.uniprot.org/uniprot/#_P48346-mappedCitation-20538758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20538758 |