| http://purl.uniprot.org/citations/20538911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20538911 | http://www.w3.org/2000/01/rdf-schema#comment | "A conserved DNA repair response is defective in the human genetic illness Fanconi anemia (FA). Mutation of some FA genes impairs homologous recombination and error-prone DNA repair, rendering FA cells sensitive to DNA cross-linking agents. We found a genetic interaction between the FA gene FANCC and the nonhomologous end joining (NHEJ) factor Ku70. Disruption of both FANCC and Ku70 suppresses sensitivity to cross-linking agents, diminishes chromosome breaks, and reverses defective homologous recombination. Ku70 binds directly to free DNA ends, committing them to NHEJ repair. We show that purified FANCD2, a downstream effector of the FA pathway, might antagonize Ku70 activity by modifying such DNA substrates. These results reveal a function for the FA pathway in processing DNA ends, thereby diverting double-strand break repair away from abortive NHEJ and toward homologous recombination."xsd:string |
| http://purl.uniprot.org/citations/20538911 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1192277"xsd:string |
| http://purl.uniprot.org/citations/20538911 | http://purl.uniprot.org/core/author | "Rosado I.V."xsd:string |
| http://purl.uniprot.org/citations/20538911 | http://purl.uniprot.org/core/author | "Pace P."xsd:string |
| http://purl.uniprot.org/citations/20538911 | http://purl.uniprot.org/core/author | "Patel K.J."xsd:string |
| http://purl.uniprot.org/citations/20538911 | http://purl.uniprot.org/core/author | "Hodskinson M.R."xsd:string |
| http://purl.uniprot.org/citations/20538911 | http://purl.uniprot.org/core/author | "Mosedale G."xsd:string |
| http://purl.uniprot.org/citations/20538911 | http://purl.uniprot.org/core/author | "Sivasubramaniam M."xsd:string |
| http://purl.uniprot.org/citations/20538911 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20538911 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/20538911 | http://purl.uniprot.org/core/pages | "219-223"xsd:string |
| http://purl.uniprot.org/citations/20538911 | http://purl.uniprot.org/core/title | "Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway."xsd:string |
| http://purl.uniprot.org/citations/20538911 | http://purl.uniprot.org/core/volume | "329"xsd:string |
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