| http://purl.uniprot.org/citations/20541250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20541250 | http://www.w3.org/2000/01/rdf-schema#comment | "Macroautophagy is a lysosomal degradative pathway essential for neuron survival. Here, we show that macroautophagy requires the Alzheimer's disease (AD)-related protein presenilin-1 (PS1). In PS1 null blastocysts, neurons from mice hypomorphic for PS1 or conditionally depleted of PS1, substrate proteolysis and autophagosome clearance during macroautophagy are prevented as a result of a selective impairment of autolysosome acidification and cathepsin activation. These deficits are caused by failed PS1-dependent targeting of the v-ATPase V0a1 subunit to lysosomes. N-glycosylation of the V0a1 subunit, essential for its efficient ER-to-lysosome delivery, requires the selective binding of PS1 holoprotein to the unglycosylated subunit and the Sec61alpha/oligosaccharyltransferase complex. PS1 mutations causing early-onset AD produce a similar lysosomal/autophagy phenotype in fibroblasts from AD patients. PS1 is therefore essential for v-ATPase targeting to lysosomes, lysosome acidification, and proteolysis during autophagy. Defective lysosomal proteolysis represents a basis for pathogenic protein accumulations and neuronal cell death in AD and suggests previously unidentified therapeutic targets."xsd:string |
| http://purl.uniprot.org/citations/20541250 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2010.05.008"xsd:string |
| http://purl.uniprot.org/citations/20541250 | http://purl.uniprot.org/core/author | "Lee J.H."xsd:string |
| http://purl.uniprot.org/citations/20541250 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/20541250 | http://purl.uniprot.org/core/author | "Kumar A."xsd:string |
| http://purl.uniprot.org/citations/20541250 | http://purl.uniprot.org/core/author | "Yu W.H."xsd:string |
| http://purl.uniprot.org/citations/20541250 | http://purl.uniprot.org/core/author | "Cuervo A.M."xsd:string |
| http://purl.uniprot.org/citations/20541250 | http://purl.uniprot.org/core/author | "Uchiyama Y."xsd:string |
| http://purl.uniprot.org/citations/20541250 | http://purl.uniprot.org/core/author | "Nixon R.A."xsd:string |
| http://purl.uniprot.org/citations/20541250 | http://purl.uniprot.org/core/author | "Peterhoff C.M."xsd:string |
| http://purl.uniprot.org/citations/20541250 | http://purl.uniprot.org/core/author | "Westaway D."xsd:string |
| http://purl.uniprot.org/citations/20541250 | http://purl.uniprot.org/core/author | "Massey A.C."xsd:string |
| http://purl.uniprot.org/citations/20541250 | http://purl.uniprot.org/core/author | "Martinez-Vicente M."xsd:string |
| http://purl.uniprot.org/citations/20541250 | http://purl.uniprot.org/core/author | "Wolfe D.M."xsd:string |
| http://purl.uniprot.org/citations/20541250 | http://purl.uniprot.org/core/author | "Mohan P.S."xsd:string |
| http://purl.uniprot.org/citations/20541250 | http://purl.uniprot.org/core/author | "Sovak G."xsd:string |
| http://purl.uniprot.org/citations/20541250 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20541250 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/20541250 | http://purl.uniprot.org/core/pages | "1146-1158"xsd:string |
| http://purl.uniprot.org/citations/20541250 | http://purl.uniprot.org/core/title | "Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations."xsd:string |
| http://purl.uniprot.org/citations/20541250 | http://purl.uniprot.org/core/volume | "141"xsd:string |
| http://purl.uniprot.org/citations/20541250 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20541250 |
| http://purl.uniprot.org/citations/20541250 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20541250 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0D3-mappedCitation-20541250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20541250 |