| http://purl.uniprot.org/citations/20547133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20547133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20547133 | http://www.w3.org/2000/01/rdf-schema#comment | "Central nervous system synapses undergo activity-dependent alterations to support learning and memory. Long-term depression (LTD) reflects a sustained reduction of the synaptic AMPA receptor content based on targeted clathrin-mediated endocytosis. Here we report a current-independent form of AMPA receptor signaling, fundamental for LTD. We found that AMPA receptors directly interact via the GluA2 subunit with the synaptic protein BRAG2, which functions as a guanine-nucleotide exchange factor (GEF) for the coat-recruitment GTPase Arf6. BRAG2-mediated catalysis, controlled by ligand-binding and tyrosine phosphorylation of GluA2, activates Arf6 to internalize synaptic AMPA receptors upon LTD induction. Furthermore, acute blockade of the GluA2-BRAG2 interaction and targeted deletion of BRAG2 in mature hippocampal CA1 pyramidal neurons prevents LTD in CA3-to-CA1 cell synapses, irrespective of the induction pathway. We conclude that BRAG2-mediated Arf6 activation triggered by AMPA receptors is the convergent step of different forms of LTD, thus providing an essential mechanism for the control of vesicle formation by endocytic cargo."xsd:string |
| http://purl.uniprot.org/citations/20547133 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2010.05.003"xsd:string |
| http://purl.uniprot.org/citations/20547133 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2010.05.003"xsd:string |
| http://purl.uniprot.org/citations/20547133 | http://purl.uniprot.org/core/author | "Scholz R."xsd:string |
| http://purl.uniprot.org/citations/20547133 | http://purl.uniprot.org/core/author | "Scholz R."xsd:string |
| http://purl.uniprot.org/citations/20547133 | http://purl.uniprot.org/core/author | "Kornau H.C."xsd:string |
| http://purl.uniprot.org/citations/20547133 | http://purl.uniprot.org/core/author | "Kornau H.C."xsd:string |
| http://purl.uniprot.org/citations/20547133 | http://purl.uniprot.org/core/author | "Koehr G."xsd:string |
| http://purl.uniprot.org/citations/20547133 | http://purl.uniprot.org/core/author | "Koehr G."xsd:string |
| http://purl.uniprot.org/citations/20547133 | http://purl.uniprot.org/core/author | "Berberich S."xsd:string |
| http://purl.uniprot.org/citations/20547133 | http://purl.uniprot.org/core/author | "Berberich S."xsd:string |
| http://purl.uniprot.org/citations/20547133 | http://purl.uniprot.org/core/author | "Kolleker A."xsd:string |
| http://purl.uniprot.org/citations/20547133 | http://purl.uniprot.org/core/author | "Kolleker A."xsd:string |
| http://purl.uniprot.org/citations/20547133 | http://purl.uniprot.org/core/author | "Rathgeber L."xsd:string |
| http://purl.uniprot.org/citations/20547133 | http://purl.uniprot.org/core/author | "Rathgeber L."xsd:string |
| http://purl.uniprot.org/citations/20547133 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20547133 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20547133 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/20547133 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/20547133 | http://purl.uniprot.org/core/pages | "768-780"xsd:string |
| http://purl.uniprot.org/citations/20547133 | http://purl.uniprot.org/core/pages | "768-780"xsd:string |
| http://purl.uniprot.org/citations/20547133 | http://purl.uniprot.org/core/title | "AMPA receptor signaling through BRAG2 and Arf6 critical for long-term synaptic depression."xsd:string |
| http://purl.uniprot.org/citations/20547133 | http://purl.uniprot.org/core/title | "AMPA receptor signaling through BRAG2 and Arf6 critical for long-term synaptic depression."xsd:string |