| http://purl.uniprot.org/citations/20547853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20547853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20547853 | http://www.w3.org/2000/01/rdf-schema#comment | "Piwi-interacting RNAs (piRNAs) comprise a broad class of small noncoding RNAs that function as an endogenous defense system against transposable elements. Here we show that the putative DExD-box helicase MOV10-like-1 (MOV10L1) is essential for silencing retrotransposons in the mouse male germline. Mov10l1 is specifically expressed in germ cells with increasing expression from gonocytes/type A spermatogonia to pachytene spermatocytes. Primary spermatocytes of Mov10l1(-/-) mice show activation of LTR and LINE-1 retrotransposons, followed by cell death, causing male infertility and a complete block of spermatogenesis at early prophase of meiosis I. Despite the early expression of Mov10l1, germline stem cell maintenance appears unaffected in Mov10l1(-/-) mice. MOV10L1 interacts with the Piwi proteins MILI and MIWI. MOV10L1 also interacts with heat shock 70-kDa protein 2 (HSPA2), a testis-enriched chaperone expressed in pachytene spermatocytes and also essential for male fertility. These studies reveal a crucial role of MOV10L1 in male fertility and piRNA-directed retrotransposon silencing in male germ cells and suggest that MOV10L1 functions as a key component of a safeguard mechanism for the genetic information in male germ cells of mammals."xsd:string |
| http://purl.uniprot.org/citations/20547853 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1007158107"xsd:string |
| http://purl.uniprot.org/citations/20547853 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1007158107"xsd:string |
| http://purl.uniprot.org/citations/20547853 | http://purl.uniprot.org/core/author | "Qi X."xsd:string |
| http://purl.uniprot.org/citations/20547853 | http://purl.uniprot.org/core/author | "Qi X."xsd:string |
| http://purl.uniprot.org/citations/20547853 | http://purl.uniprot.org/core/author | "Bassel-Duby R."xsd:string |
| http://purl.uniprot.org/citations/20547853 | http://purl.uniprot.org/core/author | "Bassel-Duby R."xsd:string |
| http://purl.uniprot.org/citations/20547853 | http://purl.uniprot.org/core/author | "Olson E.N."xsd:string |
| http://purl.uniprot.org/citations/20547853 | http://purl.uniprot.org/core/author | "Olson E.N."xsd:string |
| http://purl.uniprot.org/citations/20547853 | http://purl.uniprot.org/core/author | "Richardson J.A."xsd:string |
| http://purl.uniprot.org/citations/20547853 | http://purl.uniprot.org/core/author | "Richardson J.A."xsd:string |
| http://purl.uniprot.org/citations/20547853 | http://purl.uniprot.org/core/author | "Hamra F.K."xsd:string |
| http://purl.uniprot.org/citations/20547853 | http://purl.uniprot.org/core/author | "Hamra F.K."xsd:string |
| http://purl.uniprot.org/citations/20547853 | http://purl.uniprot.org/core/author | "Frost R.J."xsd:string |
| http://purl.uniprot.org/citations/20547853 | http://purl.uniprot.org/core/author | "Frost R.J."xsd:string |
| http://purl.uniprot.org/citations/20547853 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20547853 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20547853 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/20547853 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/20547853 | http://purl.uniprot.org/core/pages | "11847-11852"xsd:string |
| http://purl.uniprot.org/citations/20547853 | http://purl.uniprot.org/core/pages | "11847-11852"xsd:string |
| http://purl.uniprot.org/citations/20547853 | http://purl.uniprot.org/core/title | "MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs."xsd:string |
| http://purl.uniprot.org/citations/20547853 | http://purl.uniprot.org/core/title | "MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs."xsd:string |