| http://purl.uniprot.org/citations/20548030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20548030 | http://www.w3.org/2000/01/rdf-schema#comment | "Individuals with atopic dermatitis immunized with the small pox vaccine, vaccinia virus (VV), are susceptible to eczema vaccinatum (EV), a potentially fatal disseminated infection. Dysfunction of Forkhead box P3 (FoxP3)-positive regulatory T cells (Treg) has been implicated in the pathogenesis of atopic dermatitis. To test whether Treg deficiency predisposes to EV, we percutaneously VV infected FoxP3-deficient (FoxP3(KO)) mice, which completely lack FoxP3(+) Treg. These animals generated both fewer VV-specific CD8(+) effector T cells and IFN-gamma-producing CD8(+) T cells than controls, had higher viral loads, and exhibited abnormal Th2-polarized responses to the virus. To focus on the consequences of Treg deficiency confined to the skin, we generated mixed CCR4(KO) FoxP3(KO) bone marrow (CCR4/FoxP3) chimeras in which skin, but not other tissues or central lymphoid organs, lack Treg. Like FoxP3(KO) mice, the chimeras had impaired VV-specific effector T cell responses and higher viral loads. Skin cytokine expression was significantly altered in infected chimeras compared with controls. Levels of the antiviral cytokines, type I and II IFNs and IL-12, were reduced, whereas expression of the proinflammatory cytokines, IL-6, IL-10, TGF-beta, and IL-23, was increased. Importantly, infection of CCR4/FoxP3 chimeras by a noncutaneous route (i.p.) induced immune responses comparable to controls. Our findings implicate allergic skin inflammation resulting from local Treg deficiency in the pathogenesis of EV."xsd:string |
| http://purl.uniprot.org/citations/20548030 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0903144"xsd:string |
| http://purl.uniprot.org/citations/20548030 | http://purl.uniprot.org/core/author | "Chatila T.A."xsd:string |
| http://purl.uniprot.org/citations/20548030 | http://purl.uniprot.org/core/author | "Wurbel M.A."xsd:string |
| http://purl.uniprot.org/citations/20548030 | http://purl.uniprot.org/core/author | "Campbell J.J."xsd:string |
| http://purl.uniprot.org/citations/20548030 | http://purl.uniprot.org/core/author | "Manjunath N."xsd:string |
| http://purl.uniprot.org/citations/20548030 | http://purl.uniprot.org/core/author | "Laouar A."xsd:string |
| http://purl.uniprot.org/citations/20548030 | http://purl.uniprot.org/core/author | "Oettgen H.C."xsd:string |
| http://purl.uniprot.org/citations/20548030 | http://purl.uniprot.org/core/author | "Diaz N."xsd:string |
| http://purl.uniprot.org/citations/20548030 | http://purl.uniprot.org/core/author | "Hofer M.D."xsd:string |
| http://purl.uniprot.org/citations/20548030 | http://purl.uniprot.org/core/author | "Mathias C.B."xsd:string |
| http://purl.uniprot.org/citations/20548030 | http://purl.uniprot.org/core/author | "Freyschmidt E.J."xsd:string |
| http://purl.uniprot.org/citations/20548030 | http://purl.uniprot.org/core/author | "MacArthur D.H."xsd:string |
| http://purl.uniprot.org/citations/20548030 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20548030 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/20548030 | http://purl.uniprot.org/core/pages | "1295-1302"xsd:string |
| http://purl.uniprot.org/citations/20548030 | http://purl.uniprot.org/core/title | "Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses."xsd:string |
| http://purl.uniprot.org/citations/20548030 | http://purl.uniprot.org/core/volume | "185"xsd:string |
| http://purl.uniprot.org/citations/20548030 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20548030 |
| http://purl.uniprot.org/citations/20548030 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20548030 |
| http://purl.uniprot.org/uniprot/#_A0A1L1STS0-mappedCitation-20548030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20548030 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EC35-mappedCitation-20548030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20548030 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EC46-mappedCitation-20548030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20548030 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EI60-mappedCitation-20548030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20548030 |