| http://purl.uniprot.org/citations/20549717 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20549717 | http://www.w3.org/2000/01/rdf-schema#comment | "C. elegans shows dauer-like larvae formation upon cholesterol starvation (CS), but the genetic epistasis among abnormal dauer formation (daf) genes during the process remains unclear. To clarify the genetic interactions among daf-9, daf-12, and daf-16 in this process, mRNA levels of these genes upon CS were measured. CS increased the mRNA levels of daf-9, daf-12, and daf-16. CS also induced DAF-16 nuclear localization, which was positively and negatively regulated by DAF-12 and DAF-9 activities, respectively. Activated DAF-16, a FOXO transcription factor, enhanced daf-12 but suppressed daf-9 expression, whereas DAF-9 inhibited daf-12 expression. Concomitantly, CS-induced larval arrest was regulated positively by DAF-12 and DAF-16, but negatively by DAF-9. The larval arrest in daf-9 mutant was suppressed by daf-12 RNAi, placing DAF-12 downstream of DAF-9. These results altogether suggest that circulatory mutual regulation among daf-9, daf-12, and daf-16 at the expression level mediates cholesterol signal to control larval development upon CS."xsd:string |
| http://purl.uniprot.org/citations/20549717 | http://purl.org/dc/terms/identifier | "doi:10.1002/dvdy.22322"xsd:string |
| http://purl.uniprot.org/citations/20549717 | http://purl.uniprot.org/core/author | "Kawasaki I."xsd:string |
| http://purl.uniprot.org/citations/20549717 | http://purl.uniprot.org/core/author | "Shim Y.H."xsd:string |
| http://purl.uniprot.org/citations/20549717 | http://purl.uniprot.org/core/author | "Jeong M.H."xsd:string |
| http://purl.uniprot.org/citations/20549717 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20549717 | http://purl.uniprot.org/core/name | "Dev Dyn"xsd:string |
| http://purl.uniprot.org/citations/20549717 | http://purl.uniprot.org/core/pages | "1931-1940"xsd:string |
| http://purl.uniprot.org/citations/20549717 | http://purl.uniprot.org/core/title | "A circulatory transcriptional regulation among daf-9, daf-12, and daf-16 mediates larval development upon cholesterol starvation in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/20549717 | http://purl.uniprot.org/core/volume | "239"xsd:string |
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