| http://purl.uniprot.org/citations/20550516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20550516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20550516 | http://www.w3.org/2000/01/rdf-schema#comment | "The insulin-like signalling pathway is a central regulator of development, metabolism, stress resistance and lifespan in eukaryotes. Caenorhabditis elegans daf-2(e1370) animals with a loss-of-function mutation in the insulin-like receptor live twice as long as wild-type animals, and the additional knockout of the intestinal di- and tripeptide transporter pept-1 further increases lifespan by 60%. In assessing the underlying molecular mechanisms for this phenomenon, microarray-based transcriptome data sets of daf-2(e1370) and daf-2(e1370);pept-1(lg601) animals were compared with a focus on genes that showed significantly higher changes in expression levels in daf-2;pept-1 than in daf-2. We identified 187 genes with at least fourfold decreased transcript levels and 170 with more than a fourfold increase. A large fraction of the down-regulated genes encode proteins involved in germline proliferation and reproduction. The DAF-9/DAF-12 signalling cascade was identified as a prime pathway that mediates the longevity of daf-2;pept-1 with a strict dependance on DAF-16. Loss of DAF-9/DAF-12 or KRI-1 reduces the lifespan of daf-2;pept-1 to that of the daf-2 mutant. Amongst the DAF-16 target genes, numerous enzymes involved in the defence of reactive oxygen species were with increased expression level in daf-2;pept-1. On a functional level, it was demonstrated that amongst those, a high de novo synthesis rate of glutathione is most important for the longevity phenotype of this strain. Taken together, a close interdependence of endocrine hormone signalling from germline to intestine was identified as an essential element in the control of the extreme longevity of C. elegans lacking a proper function of the insulin receptor and lacking the intestinal peptide transporter."xsd:string |
| http://purl.uniprot.org/citations/20550516 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1474-9726.2010.00591.x"xsd:string |
| http://purl.uniprot.org/citations/20550516 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1474-9726.2010.00591.x"xsd:string |
| http://purl.uniprot.org/citations/20550516 | http://purl.uniprot.org/core/author | "Hu H."xsd:string |
| http://purl.uniprot.org/citations/20550516 | http://purl.uniprot.org/core/author | "Hu H."xsd:string |
| http://purl.uniprot.org/citations/20550516 | http://purl.uniprot.org/core/author | "Daniel H."xsd:string |
| http://purl.uniprot.org/citations/20550516 | http://purl.uniprot.org/core/author | "Daniel H."xsd:string |
| http://purl.uniprot.org/citations/20550516 | http://purl.uniprot.org/core/author | "Spanier B."xsd:string |
| http://purl.uniprot.org/citations/20550516 | http://purl.uniprot.org/core/author | "Spanier B."xsd:string |
| http://purl.uniprot.org/citations/20550516 | http://purl.uniprot.org/core/author | "Rubio-Aliaga I."xsd:string |
| http://purl.uniprot.org/citations/20550516 | http://purl.uniprot.org/core/author | "Rubio-Aliaga I."xsd:string |
| http://purl.uniprot.org/citations/20550516 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20550516 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20550516 | http://purl.uniprot.org/core/name | "Aging Cell"xsd:string |
| http://purl.uniprot.org/citations/20550516 | http://purl.uniprot.org/core/name | "Aging Cell"xsd:string |
| http://purl.uniprot.org/citations/20550516 | http://purl.uniprot.org/core/pages | "636-646"xsd:string |
| http://purl.uniprot.org/citations/20550516 | http://purl.uniprot.org/core/pages | "636-646"xsd:string |
| http://purl.uniprot.org/citations/20550516 | http://purl.uniprot.org/core/title | "Altered signalling from germline to intestine pushes daf-2;pept-1 Caenorhabditis elegans into extreme longevity."xsd:string |
| http://purl.uniprot.org/citations/20550516 | http://purl.uniprot.org/core/title | "Altered signalling from germline to intestine pushes daf-2;pept-1 Caenorhabditis elegans into extreme longevity."xsd:string |
| http://purl.uniprot.org/citations/20550516 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/20550516 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/20550516 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20550516 |
| http://purl.uniprot.org/citations/20550516 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20550516 |