Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/20550778http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20550778http://www.w3.org/2000/01/rdf-schema#comment"

Setting

Tuberculous rheumatism (Poncet's disease) is a reactive polyarthropathy associated with extra-pulmonary and pulmonary tuberculosis (TB) without evidence of mycobacterial infection of the involved joints. As all patients with TB do not present with this peculiar clinical feature, a genetic susceptibility is suspected.

Objective

To determine the major histocompatibility complex (MHC) class I and II alleles in Mexican mestizo patients with Poncet's disease.

Design

In this case-control study of 16 Mexican mestizo patients diagnosed with Poncet's disease and 99 ethnically matched healthy controls, high resolution human leukocyte antigen (HLA) typing was performed for HLA-A, B, DR and DQ by polymerase chain reaction. HLA-DRB1 and HLA-DQB1 subtypes were performed by sequence-specific oligonucleotide probe hybridization.

Results

A significantly increased frequency of HLA-B27 (corrected P = 0.01) and DQB1*0301 (corrected P = 0.0009) alleles and decreased frequency of HLA-DQB1*0302 (corrected P = 0.00001) were identified in patients compared to healthy controls.

Conclusion

These data suggest that genes located within the MHC may play a role in the susceptibility to Poncet's disease in patients diagnosed with TB."xsd:string
http://purl.uniprot.org/citations/20550778http://purl.uniprot.org/core/author"Granados J."xsd:string
http://purl.uniprot.org/citations/20550778http://purl.uniprot.org/core/author"Vargas-Alarcon G."xsd:string
http://purl.uniprot.org/citations/20550778http://purl.uniprot.org/core/author"Yamamoto-Furusho J.K."xsd:string
http://purl.uniprot.org/citations/20550778http://purl.uniprot.org/core/author"Barbosa-Cobos R.E."xsd:string
http://purl.uniprot.org/citations/20550778http://purl.uniprot.org/core/author"Delgado-Ochoa D."xsd:string
http://purl.uniprot.org/citations/20550778http://purl.uniprot.org/core/author"Lugo-Zamudio G.E."xsd:string
http://purl.uniprot.org/citations/20550778http://purl.uniprot.org/core/author"Nunez-Farfan R.M."xsd:string
http://purl.uniprot.org/citations/20550778http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20550778http://purl.uniprot.org/core/name"Int J Tuberc Lung Dis"xsd:string
http://purl.uniprot.org/citations/20550778http://purl.uniprot.org/core/pages"916-920"xsd:string
http://purl.uniprot.org/citations/20550778http://purl.uniprot.org/core/title"Human leukocyte antigen typing in tuberculous rheumatism: Poncet's disease."xsd:string
http://purl.uniprot.org/citations/20550778http://purl.uniprot.org/core/volume"14"xsd:string
http://purl.uniprot.org/citations/20550778http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20550778
http://purl.uniprot.org/citations/20550778http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20550778
http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-20550778http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20550778
http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-20550778http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20550778
http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-20550778http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20550778
http://purl.uniprot.org/uniprot/#_A0A0A7C543-mappedCitation-20550778http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20550778
http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-20550778http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20550778
http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-20550778http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20550778
http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-20550778http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20550778
http://purl.uniprot.org/uniprot/#_A0A0E3DC97-mappedCitation-20550778http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20550778
http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-20550778http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20550778
▶