Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/20550877http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20550877http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the effects of Radix Ginseng and Radix Notoginseng formula on expressions of vascular endothelial growth factor receptor-2 (VEGFR-2) and hypoxia-inducible factor-1alpha (HIF-1alpha) in ischemic myocardium of rats with acute myocardial infarction.

Methods

A total of 100 Wistar rats were randomly divided into normal control group, sham-operated group, untreated group, metoprolol (Betaloc) group, and high- and low-dose Radix Ginseng and Radix Notoginseng formula groups. Acute myocardial infarction was induced in the untreated group, Betaloc group, and high- and low-dose Radix Ginseng and Radix Notoginseng formula groups by left anterior descending coronary artery ligation. After 12-day treatment, microvessel density (MVD) in ischemic myocardium was detected by immunohistochemical method, while expressions of VEGFR-2 and HIF-1alpha proteins were detected by Western blotting, and expressions of VEGFR-2 and HIF-1alpha mRNAs were detected by real-time fluorescent quantitative polymerase chain reaction.

Results

MVD in the untreated group was increased significantly, higher than those in the normal control group and the sham-operated group (P<0.05) and lower than those in the high- and low-dose Radix Ginseng and Radix Notoginseng formula groups and Betaloc group (P<0.01). VEGFR-2 and HIF-1alpha protein and mRNA expressions in the untreated group were higher than those in the normal control group and the sham-operated group (P<0.05). VEGFR-2 and HIF-1alpha protein and mRNA expressions in the high- and low-dose Radix Ginseng and Radix Notoginseng formula groups and Betaloc group were higher than those in the untreated group (P<0.05). There was a significant difference between the high- and low-dose Radix Ginseng and Radix Notoginseng formula groups (P<0.05).

Conclusion

Radix Ginseng and Radix Notoginseng extract can up-regulate the protein and mRNA expressions of VEGFR-2 and HIF-1alpha and increase MVD in ischemic myocardium to improve myocardial ischemia so as to promote the development of collateral circulation."xsd:string
http://purl.uniprot.org/citations/20550877http://purl.org/dc/terms/identifier"doi:10.3736/jcim20100607"xsd:string
http://purl.uniprot.org/citations/20550877http://purl.uniprot.org/core/author"Lei Y."xsd:string
http://purl.uniprot.org/citations/20550877http://purl.uniprot.org/core/author"Yang J."xsd:string
http://purl.uniprot.org/citations/20550877http://purl.uniprot.org/core/author"DU X.J."xsd:string
http://purl.uniprot.org/citations/20550877http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20550877http://purl.uniprot.org/core/name"Zhong Xi Yi Jie He Xue Bao"xsd:string
http://purl.uniprot.org/citations/20550877http://purl.uniprot.org/core/pages"548-553"xsd:string
http://purl.uniprot.org/citations/20550877http://purl.uniprot.org/core/title"[Effects of Radix Ginseng and Radix Notoginseng formula on expressions of vascular endothelial growth factor receptor-2 and hypoxia-inducible factor-1alpha in ischemic myocardium of rats with acute myocardial infarction]."xsd:string
http://purl.uniprot.org/citations/20550877http://purl.uniprot.org/core/volume"8"xsd:string
http://purl.uniprot.org/citations/20550877http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20550877
http://purl.uniprot.org/citations/20550877http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20550877
http://purl.uniprot.org/uniprot/#_A0A9K3Y7B7-mappedCitation-20550877http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20550877
http://purl.uniprot.org/uniprot/#_A6HC66-mappedCitation-20550877http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20550877
http://purl.uniprot.org/uniprot/#_A6HC67-mappedCitation-20550877http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20550877
http://purl.uniprot.org/uniprot/#_A6JCZ2-mappedCitation-20550877http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20550877
http://purl.uniprot.org/uniprot/#_A6JCZ4-mappedCitation-20550877http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20550877
http://purl.uniprot.org/uniprot/#_O35800-mappedCitation-20550877http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20550877
http://purl.uniprot.org/uniprot/#_O08775-mappedCitation-20550877http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20550877
http://purl.uniprot.org/uniprot/A6HC66http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/20550877
http://purl.uniprot.org/uniprot/A0A9K3Y7B7http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/20550877
http://purl.uniprot.org/uniprot/A6HC67http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/20550877
http://purl.uniprot.org/uniprot/A6JCZ2http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/20550877
http://purl.uniprot.org/uniprot/A6JCZ4http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/20550877
▶