| http://purl.uniprot.org/citations/20554525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20554525 | http://www.w3.org/2000/01/rdf-schema#comment | "Most anaplastic large cell lymphomas (ALCL) express oncogenic fusion proteins derived from chromosomal translocations or inversions of the anaplastic lymphoma kinase (ALK) gene. Frequently ALCL carry the t(2;5) translocation, which fuses the ALK gene to the nucleophosmin (NPM1) gene. The transforming activity mediated by NPM-ALK fusion induces different pathways that control proliferation and survival of lymphoma cells. Grb2 is an adaptor protein thought to play an important role in ALK-mediated transformation, but its interaction with NPM-ALK, as well as its function in regulating ALCL signaling pathways and cell growth, has never been elucidated. Here we show that active NPM-ALK, but not a kinase-dead mutant, bound and induced Grb2 phosphorylation in tyrosine 160. An intact SH3 domain at the C terminus of Grb2 was required for Tyr(160) phosphorylation. Furthermore, Grb2 did not bind to a single region but rather to different regions of NPM-ALK, mainly Tyr(152-156), Tyr(567), and a proline-rich region, Pro(415-417). Finally, shRNA knockdown experiments showed that Grb2 regulates primarily the NPM-ALK-mediated phosphorylation of SHP2 and plays a key role in ALCL cell growth."xsd:string |
| http://purl.uniprot.org/citations/20554525 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.116327"xsd:string |
| http://purl.uniprot.org/citations/20554525 | http://purl.uniprot.org/core/author | "Chiarle R."xsd:string |
| http://purl.uniprot.org/citations/20554525 | http://purl.uniprot.org/core/author | "Ambrogio C."xsd:string |
| http://purl.uniprot.org/citations/20554525 | http://purl.uniprot.org/core/author | "Riera L."xsd:string |
| http://purl.uniprot.org/citations/20554525 | http://purl.uniprot.org/core/author | "Voena C."xsd:string |
| http://purl.uniprot.org/citations/20554525 | http://purl.uniprot.org/core/author | "Surrenti N."xsd:string |
| http://purl.uniprot.org/citations/20554525 | http://purl.uniprot.org/core/author | "Lasorsa E."xsd:string |
| http://purl.uniprot.org/citations/20554525 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20554525 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/20554525 | http://purl.uniprot.org/core/pages | "26441-26450"xsd:string |
| http://purl.uniprot.org/citations/20554525 | http://purl.uniprot.org/core/title | "Involvement of Grb2 adaptor protein in nucleophosmin-anaplastic lymphoma kinase (NPM-ALK)-mediated signaling and anaplastic large cell lymphoma growth."xsd:string |
| http://purl.uniprot.org/citations/20554525 | http://purl.uniprot.org/core/volume | "285"xsd:string |
| http://purl.uniprot.org/citations/20554525 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20554525 |
| http://purl.uniprot.org/citations/20554525 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20554525 |
| http://purl.uniprot.org/uniprot/#_A0A0K2YUJ3-mappedCitation-20554525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20554525 |
| http://purl.uniprot.org/uniprot/#_A0A140VJQ2-mappedCitation-20554525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20554525 |
| http://purl.uniprot.org/uniprot/#_D1MAM4-mappedCitation-20554525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20554525 |
| http://purl.uniprot.org/uniprot/#_D1MAM5-mappedCitation-20554525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20554525 |
| http://purl.uniprot.org/uniprot/#_A0A384ME16-mappedCitation-20554525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20554525 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z491-mappedCitation-20554525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20554525 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4G7-mappedCitation-20554525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20554525 |
| http://purl.uniprot.org/uniprot/#_B0LPF3-mappedCitation-20554525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20554525 |
| http://purl.uniprot.org/uniprot/#_A4ZU86-mappedCitation-20554525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20554525 |