| http://purl.uniprot.org/citations/20554964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20554964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20554964 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-17 mediates essential inflammatory responses in host defense and autoimmunity. The IL-17A-IL-17F signaling complex is composed of IL-17RA and IL-17RC, both of which are necessary for signal transduction. To date, the specific contribution of IL-17RC to downstream signaling remains poorly understood. To define the regions within the IL-17RC cytoplasmic tail required for signal transduction, we assayed signaling by a panel of IL-17RC deletion mutants. These findings reveal that IL-17RC inducibly associates with a specific glycosylated IL-17RA isoform, in a manner independent of the IL-17RC cytoplasmic tail. Using expression of the IL-17 target genes IL-6 and 24p3/lipocalin-2 as a readout, functional reconstitution of signaling in IL-17RC(-/-) fibroblasts required the SEF/IL-17R signaling domain (SEFIR), a conserved motif common to IL-17R family members. Unexpectedly, the IL-17RC SEFIR alone was not sufficient to reconstitute IL-17-dependent signaling. Rather, an additional sequence downstream of the SEFIR was also necessary. We further found that IL-17RC interacts directly with the adaptor/E3 ubiquitin ligase Act1, and that the functional IL-17RC isoforms containing the extended SEFIR region interact specifically with a phosphorylated isoform of Act1. Finally, we show that IL-17RC is required for in vivo IL-17-dependent responses during oral mucosal infections caused by the human commensal fungus Candida albicans. These results indicate that IL-17RC is vital for IL-17-dependent signaling both in vitro and in vivo. Insight into the mechanisms by which IL-17RC signals helps shed light on IL-17-dependent inflammatory responses and may ultimately provide an avenue for therapeutic intervention in IL-17-mediated diseases."xsd:string |
| http://purl.uniprot.org/citations/20554964 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0903739"xsd:string |
| http://purl.uniprot.org/citations/20554964 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0903739"xsd:string |
| http://purl.uniprot.org/citations/20554964 | http://purl.uniprot.org/core/author | "Patel N."xsd:string |
| http://purl.uniprot.org/citations/20554964 | http://purl.uniprot.org/core/author | "Patel N."xsd:string |
| http://purl.uniprot.org/citations/20554964 | http://purl.uniprot.org/core/author | "Shen F."xsd:string |
| http://purl.uniprot.org/citations/20554964 | http://purl.uniprot.org/core/author | "Shen F."xsd:string |
| http://purl.uniprot.org/citations/20554964 | http://purl.uniprot.org/core/author | "Kolls J.K."xsd:string |
| http://purl.uniprot.org/citations/20554964 | http://purl.uniprot.org/core/author | "Kolls J.K."xsd:string |
| http://purl.uniprot.org/citations/20554964 | http://purl.uniprot.org/core/author | "Conti H.R."xsd:string |
| http://purl.uniprot.org/citations/20554964 | http://purl.uniprot.org/core/author | "Conti H.R."xsd:string |
| http://purl.uniprot.org/citations/20554964 | http://purl.uniprot.org/core/author | "Gaffen S.L."xsd:string |
| http://purl.uniprot.org/citations/20554964 | http://purl.uniprot.org/core/author | "Gaffen S.L."xsd:string |
| http://purl.uniprot.org/citations/20554964 | http://purl.uniprot.org/core/author | "Kane L.P."xsd:string |
| http://purl.uniprot.org/citations/20554964 | http://purl.uniprot.org/core/author | "Kane L.P."xsd:string |
| http://purl.uniprot.org/citations/20554964 | http://purl.uniprot.org/core/author | "Ouyang W."xsd:string |
| http://purl.uniprot.org/citations/20554964 | http://purl.uniprot.org/core/author | "Ouyang W."xsd:string |
| http://purl.uniprot.org/citations/20554964 | http://purl.uniprot.org/core/author | "Childs E.E."xsd:string |
| http://purl.uniprot.org/citations/20554964 | http://purl.uniprot.org/core/author | "Childs E.E."xsd:string |
| http://purl.uniprot.org/citations/20554964 | http://purl.uniprot.org/core/author | "Hernandez-Santos N."xsd:string |
| http://purl.uniprot.org/citations/20554964 | http://purl.uniprot.org/core/author | "Hernandez-Santos N."xsd:string |
| http://purl.uniprot.org/citations/20554964 | http://purl.uniprot.org/core/author | "Ho A.W."xsd:string |
| http://purl.uniprot.org/citations/20554964 | http://purl.uniprot.org/core/author | "Ho A.W."xsd:string |