| http://purl.uniprot.org/citations/20554967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20554967 | http://www.w3.org/2000/01/rdf-schema#comment | "The ternary complex factors (TCFs; SAP-1, Elk-1, and Net) are serum response factor cofactors that share many functional properties and are coexpressed in many tissues. SAP-1, the predominant thymus TCF, is required for thymocyte positive selection. In this study, we assessed whether the different TCFs are functionally equivalent. Elk-1 deletion, but not the hypomorphic Net(delta) mutation, exacerbated the SAP-1 positive selection phenotype, but triply deficient thymocytes were no more defective than SAP-1(-/-) Elk-1(-/-) cells. Inactivation of the other TCFs did not affect SAP-1-independent processes, including beta-selection, regulatory T cell selection, and negative selection, although reduced marginal zone B cells were observed in SAP-1(-/-) Elk-1(-/-) animals. Ectopic expression of Elk-1, but not Net, rescued positive selection of SAP-1(-/-) thymocytes; thus, SAP-1 and Elk-1 are functionally equivalent in this system, and the SAP-1 null selection phenotype reflects only its high expression in the thymus. Array analysis of TCR-stimulated double-positive cells identified SAP-1-dependent inducible genes whose transcription was further impaired in SAP-1(-/-) Elk-1(-/-) cells; thus, these genes, which include Egr-1 and Egr-2, represent candidate mediators of positive selection. Chromatin immunoprecipitation revealed subtly different promoter targeting between the different TCFs. Ectopic expression of Egr-1 restored positive selection in SAP-1 null thymocytes, establishing it (and possibly other Egr family members) as the major effector for ERK-SAP-1 signaling in thymocyte positive selection."xsd:string |
| http://purl.uniprot.org/citations/20554967 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1000472"xsd:string |
| http://purl.uniprot.org/citations/20554967 | http://purl.uniprot.org/core/author | "Nordheim A."xsd:string |
| http://purl.uniprot.org/citations/20554967 | http://purl.uniprot.org/core/author | "Treisman R."xsd:string |
| http://purl.uniprot.org/citations/20554967 | http://purl.uniprot.org/core/author | "Wasylyk B."xsd:string |
| http://purl.uniprot.org/citations/20554967 | http://purl.uniprot.org/core/author | "Willoughby J."xsd:string |
| http://purl.uniprot.org/citations/20554967 | http://purl.uniprot.org/core/author | "Nicolas R."xsd:string |
| http://purl.uniprot.org/citations/20554967 | http://purl.uniprot.org/core/author | "Costello P."xsd:string |
| http://purl.uniprot.org/citations/20554967 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20554967 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/20554967 | http://purl.uniprot.org/core/pages | "1082-1092"xsd:string |
| http://purl.uniprot.org/citations/20554967 | http://purl.uniprot.org/core/title | "Ternary complex factors SAP-1 and Elk-1, but not net, are functionally equivalent in thymocyte development."xsd:string |
| http://purl.uniprot.org/citations/20554967 | http://purl.uniprot.org/core/volume | "185"xsd:string |
| http://purl.uniprot.org/citations/20554967 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20554967 |
| http://purl.uniprot.org/citations/20554967 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20554967 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GXH8-mappedCitation-20554967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20554967 |
| http://purl.uniprot.org/uniprot/#_A9L8S9-mappedCitation-20554967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20554967 |
| http://purl.uniprot.org/uniprot/#_A9L8T0-mappedCitation-20554967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20554967 |
| http://purl.uniprot.org/uniprot/#_C7C6A8-mappedCitation-20554967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20554967 |
| http://purl.uniprot.org/uniprot/#_C7C6A9-mappedCitation-20554967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20554967 |
| http://purl.uniprot.org/uniprot/#_C7C6B0-mappedCitation-20554967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20554967 |
| http://purl.uniprot.org/uniprot/#_C7C6B1-mappedCitation-20554967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20554967 |
| http://purl.uniprot.org/uniprot/#_C7C6B2-mappedCitation-20554967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20554967 |
| http://purl.uniprot.org/uniprot/#_C7C6B3-mappedCitation-20554967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20554967 |