| http://purl.uniprot.org/citations/20558726 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20558726 | http://www.w3.org/2000/01/rdf-schema#comment | "The oncogenic protein BCL-3 activates or represses gene transcription through binding with the NF-kappaB proteins p50 and p52 and is degraded through a phospho- and GSK3-dependent pathway. However, the mechanisms underlying its degradation remain poorly understood. Yeast two-hybrid analysis led to the identification of the proteasome subunit PSMB1 as a BCL-3-associated protein. The binding of BCL-3 to PSMB1 is required for its degradation through the proteasome. Indeed, PSMB1-depleted cells are defective in degrading polyubiquitinated BCL-3. The N-terminal part of BCL-3 includes lysines 13 and 26 required for the Lys(48)-linked polyubiquitination of BCL-3. Moreover, the E3 ligase FBW7, known to polyubiquitinate a variety of substrates phosphorylated by GSK3, is dispensable for BCL-3 degradation. Thus, our data defined a unique motif of BCL-3 that is needed for its recruitment to the proteasome and identified PSMB1 as a key protein required for the proteasome-mediated degradation of a nuclear and oncogenic IkappaB protein."xsd:string |
| http://purl.uniprot.org/citations/20558726 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.112128"xsd:string |
| http://purl.uniprot.org/citations/20558726 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/20558726 | http://purl.uniprot.org/core/author | "Vanderplasschen A."xsd:string |
| http://purl.uniprot.org/citations/20558726 | http://purl.uniprot.org/core/author | "Bex F."xsd:string |
| http://purl.uniprot.org/citations/20558726 | http://purl.uniprot.org/core/author | "Robert I."xsd:string |
| http://purl.uniprot.org/citations/20558726 | http://purl.uniprot.org/core/author | "Chariot A."xsd:string |
| http://purl.uniprot.org/citations/20558726 | http://purl.uniprot.org/core/author | "Merville M.P."xsd:string |
| http://purl.uniprot.org/citations/20558726 | http://purl.uniprot.org/core/author | "Viatour P."xsd:string |
| http://purl.uniprot.org/citations/20558726 | http://purl.uniprot.org/core/author | "Shostak K."xsd:string |
| http://purl.uniprot.org/citations/20558726 | http://purl.uniprot.org/core/author | "Chapelle J.P."xsd:string |
| http://purl.uniprot.org/citations/20558726 | http://purl.uniprot.org/core/author | "Olivier S."xsd:string |
| http://purl.uniprot.org/citations/20558726 | http://purl.uniprot.org/core/author | "Gothot A."xsd:string |
| http://purl.uniprot.org/citations/20558726 | http://purl.uniprot.org/core/author | "Keutgens A."xsd:string |
| http://purl.uniprot.org/citations/20558726 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20558726 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/20558726 | http://purl.uniprot.org/core/pages | "25831-25840"xsd:string |
| http://purl.uniprot.org/citations/20558726 | http://purl.uniprot.org/core/title | "BCL-3 degradation involves its polyubiquitination through a FBW7-independent pathway and its binding to the proteasome subunit PSMB1."xsd:string |
| http://purl.uniprot.org/citations/20558726 | http://purl.uniprot.org/core/volume | "285"xsd:string |
| http://purl.uniprot.org/citations/20558726 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20558726 |
| http://purl.uniprot.org/citations/20558726 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20558726 |
| http://purl.uniprot.org/uniprot/#_G0Z2K0-mappedCitation-20558726 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20558726 |
| http://purl.uniprot.org/uniprot/#_A7BJS8-mappedCitation-20558726 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20558726 |
| http://purl.uniprot.org/uniprot/#_A0A140VK45-mappedCitation-20558726 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20558726 |