| http://purl.uniprot.org/citations/20559325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20559325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20559325 | http://www.w3.org/2000/01/rdf-schema#comment | "Prolonged stimulation of the beta2-adrenergic receptor (beta2AR) leads to receptor ubiquitination and downregulation. Using a genome-wide RNA interference screen, we identified arrestin domain-containing 3 (ARRDC3) as a gene required for beta2AR regulation. The ARRDC3 protein interacts with ubiquitin ligase neural precursor development downregulated protein 4 (NEDD4) through two conserved PPXY motifs and recruits NEDD4 to the activated receptor. The ARRDC3 protein also interacts and co-localizes with activated beta2AR. Knockdown of ARRDC3 expression abolishes the association between NEDD4 and beta2AR. Furthermore, functional inactivation of ARRDC3, either through small interfering RNA (siRNA)-mediated knockdown or overexpression of a mutant that does not interact with NEDD4, blocks receptor ubiquitination and degradation. Our results establish ARRDC3 as an essential adaptor for beta2AR ubiquitination."xsd:string |
| http://purl.uniprot.org/citations/20559325 | http://purl.org/dc/terms/identifier | "doi:10.1038/embor.2010.80"xsd:string |
| http://purl.uniprot.org/citations/20559325 | http://purl.org/dc/terms/identifier | "doi:10.1038/embor.2010.80"xsd:string |
| http://purl.uniprot.org/citations/20559325 | http://purl.uniprot.org/core/author | "Lu Q."xsd:string |
| http://purl.uniprot.org/citations/20559325 | http://purl.uniprot.org/core/author | "Lu Q."xsd:string |
| http://purl.uniprot.org/citations/20559325 | http://purl.uniprot.org/core/author | "Pan H."xsd:string |
| http://purl.uniprot.org/citations/20559325 | http://purl.uniprot.org/core/author | "Pan H."xsd:string |
| http://purl.uniprot.org/citations/20559325 | http://purl.uniprot.org/core/author | "Nabhan J.F."xsd:string |
| http://purl.uniprot.org/citations/20559325 | http://purl.uniprot.org/core/author | "Nabhan J.F."xsd:string |
| http://purl.uniprot.org/citations/20559325 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20559325 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20559325 | http://purl.uniprot.org/core/name | "EMBO Rep."xsd:string |
| http://purl.uniprot.org/citations/20559325 | http://purl.uniprot.org/core/name | "EMBO Rep."xsd:string |
| http://purl.uniprot.org/citations/20559325 | http://purl.uniprot.org/core/pages | "605-611"xsd:string |
| http://purl.uniprot.org/citations/20559325 | http://purl.uniprot.org/core/pages | "605-611"xsd:string |
| http://purl.uniprot.org/citations/20559325 | http://purl.uniprot.org/core/title | "Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the beta2-adrenergic receptor."xsd:string |
| http://purl.uniprot.org/citations/20559325 | http://purl.uniprot.org/core/title | "Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the beta2-adrenergic receptor."xsd:string |
| http://purl.uniprot.org/citations/20559325 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/20559325 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/20559325 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20559325 |
| http://purl.uniprot.org/citations/20559325 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20559325 |
| http://purl.uniprot.org/citations/20559325 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20559325 |
| http://purl.uniprot.org/citations/20559325 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20559325 |