| http://purl.uniprot.org/citations/20562105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20562105 | http://www.w3.org/2000/01/rdf-schema#comment | "Focal segmental glomerulosclerosis (FSGS) is a leading cause of nephrotic syndrome and end-stage renal disease worldwide. Although the mechanisms underlying this important disease are poorly understood, the glomerular podocyte clearly plays a central role in disease pathogenesis. In the current work, we demonstrate that the homophilic adhesion molecule sidekick-1 (sdk-1) is up-regulated in podocytes in FSGS both in rodent models and in human kidney biopsy samples. Transgenic mice that have podocyte-specific overexpression of sdk-1 develop gradually progressive heavy proteinuria and severe FSGS. We also show that sdk-1 associates with the slit diaphragm linker protein MAGI-1, which is already known to interact with several critical podocyte proteins including synaptopodin, alpha-actinin-4, nephrin, JAM4, and beta-catenin. This interaction is mediated through a direct interaction between the carboxyl terminus of sdk-1 and specific PDZ domains of MAGI-1. In vitro expression of sdk-1 enables a dramatic recruitment of MAGI-1 to the cell membrane. Furthermore, a truncated version of sdk-1 that is unable to bind to MAGI-1 does not induce podocyte dysfunction when overexpressed. We conclude that the up-regulation of sdk-1 in podocytes is an important pathogenic factor in FSGS and that the mechanism involves disruption of the actin cytoskeleton possibly via alterations in MAGI-1 function."xsd:string |
| http://purl.uniprot.org/citations/20562105 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.133959"xsd:string |
| http://purl.uniprot.org/citations/20562105 | http://purl.uniprot.org/core/author | "Hata Y."xsd:string |
| http://purl.uniprot.org/citations/20562105 | http://purl.uniprot.org/core/author | "Kurihara H."xsd:string |
| http://purl.uniprot.org/citations/20562105 | http://purl.uniprot.org/core/author | "D'Agati V.D."xsd:string |
| http://purl.uniprot.org/citations/20562105 | http://purl.uniprot.org/core/author | "Potla U."xsd:string |
| http://purl.uniprot.org/citations/20562105 | http://purl.uniprot.org/core/author | "He J.C."xsd:string |
| http://purl.uniprot.org/citations/20562105 | http://purl.uniprot.org/core/author | "Coleman S."xsd:string |
| http://purl.uniprot.org/citations/20562105 | http://purl.uniprot.org/core/author | "Klotman P.E."xsd:string |
| http://purl.uniprot.org/citations/20562105 | http://purl.uniprot.org/core/author | "Kaufman L."xsd:string |
| http://purl.uniprot.org/citations/20562105 | http://purl.uniprot.org/core/author | "Dikiy S."xsd:string |
| http://purl.uniprot.org/citations/20562105 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20562105 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/20562105 | http://purl.uniprot.org/core/pages | "25677-25685"xsd:string |
| http://purl.uniprot.org/citations/20562105 | http://purl.uniprot.org/core/title | "Up-regulation of the homophilic adhesion molecule sidekick-1 in podocytes contributes to glomerulosclerosis."xsd:string |
| http://purl.uniprot.org/citations/20562105 | http://purl.uniprot.org/core/volume | "285"xsd:string |
| http://purl.uniprot.org/citations/20562105 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20562105 |
| http://purl.uniprot.org/citations/20562105 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20562105 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SUZ0-mappedCitation-20562105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20562105 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVU9-mappedCitation-20562105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20562105 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0S6-mappedCitation-20562105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20562105 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SWA1-mappedCitation-20562105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20562105 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SWH0-mappedCitation-20562105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20562105 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SUP9-mappedCitation-20562105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20562105 |