| http://purl.uniprot.org/citations/20562864 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20562864 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20562864 | http://www.w3.org/2000/01/rdf-schema#comment | "Heterochromatin protein 1 (HP1) has an essential role in heterochromatin formation and mitotic progression through its interaction with various proteins. We have identified a unique HP1alpha-binding protein, POGZ (pogo transposable element-derived protein with zinc finger domain), using an advanced proteomics approach. Proteins generally interact with HP1 through a PxVxL (where x is any amino-acid residue) motif; however, POGZ was found to bind to HP1alpha through a zinc-finger-like motif. Binding by POGZ, mediated through its zinc-finger-like motif, competed with PxVxL proteins and destabilized the HP1alpha-chromatin interaction. Depletion experiments confirmed that the POGZ HP1-binding domain is essential for normal mitotic progression and dissociation of HP1alpha from mitotic chromosome arms. Furthermore, POGZ is required for the correct activation and dissociation of Aurora B kinase from chromosome arms during M phase. These results reveal POGZ as an essential protein that links HP1alpha dissociation with Aurora B kinase activation during mitosis."xsd:string |
| http://purl.uniprot.org/citations/20562864 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb2075"xsd:string |
| http://purl.uniprot.org/citations/20562864 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb2075"xsd:string |
| http://purl.uniprot.org/citations/20562864 | http://purl.uniprot.org/core/author | "Kimura H."xsd:string |
| http://purl.uniprot.org/citations/20562864 | http://purl.uniprot.org/core/author | "Kimura H."xsd:string |
| http://purl.uniprot.org/citations/20562864 | http://purl.uniprot.org/core/author | "Nagao K."xsd:string |
| http://purl.uniprot.org/citations/20562864 | http://purl.uniprot.org/core/author | "Nagao K."xsd:string |
| http://purl.uniprot.org/citations/20562864 | http://purl.uniprot.org/core/author | "Nozaki N."xsd:string |
| http://purl.uniprot.org/citations/20562864 | http://purl.uniprot.org/core/author | "Nozaki N."xsd:string |
| http://purl.uniprot.org/citations/20562864 | http://purl.uniprot.org/core/author | "Hirota T."xsd:string |
| http://purl.uniprot.org/citations/20562864 | http://purl.uniprot.org/core/author | "Hirota T."xsd:string |
| http://purl.uniprot.org/citations/20562864 | http://purl.uniprot.org/core/author | "Obuse C."xsd:string |
| http://purl.uniprot.org/citations/20562864 | http://purl.uniprot.org/core/author | "Obuse C."xsd:string |
| http://purl.uniprot.org/citations/20562864 | http://purl.uniprot.org/core/author | "Iwasaki O."xsd:string |
| http://purl.uniprot.org/citations/20562864 | http://purl.uniprot.org/core/author | "Iwasaki O."xsd:string |
| http://purl.uniprot.org/citations/20562864 | http://purl.uniprot.org/core/author | "Masuda H.T."xsd:string |
| http://purl.uniprot.org/citations/20562864 | http://purl.uniprot.org/core/author | "Masuda H.T."xsd:string |
| http://purl.uniprot.org/citations/20562864 | http://purl.uniprot.org/core/author | "Nozawa R.S."xsd:string |
| http://purl.uniprot.org/citations/20562864 | http://purl.uniprot.org/core/author | "Nozawa R.S."xsd:string |
| http://purl.uniprot.org/citations/20562864 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20562864 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20562864 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/20562864 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |