| http://purl.uniprot.org/citations/20566683 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20566683 | http://www.w3.org/2000/01/rdf-schema#comment | "Centromeres contain specialized nucleosomes in which histone H3 is replaced by the histone variant centromere protein A (CENP-A). CENP-A nucleosomes are thought to act as an epigenetic mark that specifies centromere identity. We previously identified CENP-N as a CENP-A nucleosome-specific binding protein. Here, we show that CENP-C also binds directly and specifically to CENP-A nucleosomes. Nucleosome binding by CENP-C required the extreme C terminus of CENP-A and did not compete with CENP-N binding, which suggests that CENP-C and CENP-N recognize distinct structural elements of CENP-A nucleosomes. A mutation that disrupted CENP-C binding to CENP-A nucleosomes in vitro caused defects in CENP-C targeting to centromeres. Moreover, depletion of CENP-C with siRNA resulted in the mislocalization of all other nonhistone CENPs examined, including CENP-K, CENP-H, CENP-I, and CENP-T, and led to a partial reduction in centromeric CENP-A. We propose that CENP-C binds directly to CENP-A chromatin and, together with CENP-N, provides the foundation upon which other centromere and kinetochore proteins are assembled."xsd:string |
| http://purl.uniprot.org/citations/20566683 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201001013"xsd:string |
| http://purl.uniprot.org/citations/20566683 | http://purl.uniprot.org/core/author | "Carroll C.W."xsd:string |
| http://purl.uniprot.org/citations/20566683 | http://purl.uniprot.org/core/author | "Straight A.F."xsd:string |
| http://purl.uniprot.org/citations/20566683 | http://purl.uniprot.org/core/author | "Milks K.J."xsd:string |
| http://purl.uniprot.org/citations/20566683 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20566683 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/20566683 | http://purl.uniprot.org/core/pages | "1143-1155"xsd:string |
| http://purl.uniprot.org/citations/20566683 | http://purl.uniprot.org/core/title | "Dual recognition of CENP-A nucleosomes is required for centromere assembly."xsd:string |
| http://purl.uniprot.org/citations/20566683 | http://purl.uniprot.org/core/volume | "189"xsd:string |
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