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http://purl.uniprot.org/citations/20568452http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20568452http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To explore the effect of heat shock protein 70(HSP70) gene polymorphism on genetic susceptibility of pneumoconiosis of coal worker (CWP).

Methods

100 workers whose sternites were assessed 0+ were chosen as the case group and 100 workers as the control. HSP70 genotypes were analyzed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.

Results

There were significantly differences in HSP70-1 b2/b2 genotype (chi2 = 8.26, P < 0.05) between the case group and the control ,the risks of CWP in the individuals with b2/b2 genotype were 2.36 times than those with b1/b1 genotype. The polymorphism of HSP70-2 and HSP70-hom had no statistics significance in the difference of the two groups.

Conclusion

The results suggested that the individual with HSP70-1 b2/b2 genotype may be a predisposing genotype to CWP and the individuals with the genotype could have weaker adaptability than the others."xsd:string
http://purl.uniprot.org/citations/20568452http://purl.uniprot.org/core/author"Li W."xsd:string
http://purl.uniprot.org/citations/20568452http://purl.uniprot.org/core/author"Liang S."xsd:string
http://purl.uniprot.org/citations/20568452http://purl.uniprot.org/core/author"Wang Y."xsd:string
http://purl.uniprot.org/citations/20568452http://purl.uniprot.org/core/author"Wu Y."xsd:string
http://purl.uniprot.org/citations/20568452http://purl.uniprot.org/core/author"Zhou F."xsd:string
http://purl.uniprot.org/citations/20568452http://purl.uniprot.org/core/author"Qin W."xsd:string
http://purl.uniprot.org/citations/20568452http://purl.uniprot.org/core/author"Yao W."xsd:string
http://purl.uniprot.org/citations/20568452http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20568452http://purl.uniprot.org/core/name"Wei Sheng Yan Jiu"xsd:string
http://purl.uniprot.org/citations/20568452http://purl.uniprot.org/core/pages"279-282"xsd:string
http://purl.uniprot.org/citations/20568452http://purl.uniprot.org/core/title"[Effect of HSP70 gene polymorphism on genetic susceptibility of pneumoconiosis of coal worker]."xsd:string
http://purl.uniprot.org/citations/20568452http://purl.uniprot.org/core/volume"39"xsd:string
http://purl.uniprot.org/citations/20568452http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20568452
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