| http://purl.uniprot.org/citations/20570605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20570605 | http://www.w3.org/2000/01/rdf-schema#comment | "Alcohol-sensitive type 1 equilibrative nucleotide transporter (ENT1) is known to regulate glutamate signaling in the striatum as well as ethanol intoxication. However, it was unclear whether altered extracellular glutamate levels in ENT1(-/-) mice contribute to ethanol-induced behavioral changes. Here we report that altered glutamate signaling in ENT1(-/-) mice is implicated in the ethanol-induced locomotion and ataxia by NMDA receptor antagonist, CGP37849. ENT1(-/-) mice appear less intoxicated following sequential treatment with CGP37849 and ethanol, compared to ENT1(+/+) littermates on the rotarod. These results indicate that inhibiting NMDA glutamate receptors is critical to regulate the response and susceptibility of alcohol related behaviors. Interestingly, a microdialysis experiment showed that the ventral striatum of ENT1(-/-) mice is less sensitive to the glutamate-reducing effect of the NMDA receptor antagonist compared to the dorsal striatum. Our findings suggest that differential glutamate neurotransmission in the striatum regulates ethanol intoxication."xsd:string |
| http://purl.uniprot.org/citations/20570605 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neulet.2010.05.079"xsd:string |
| http://purl.uniprot.org/citations/20570605 | http://purl.uniprot.org/core/author | "Choi D.S."xsd:string |
| http://purl.uniprot.org/citations/20570605 | http://purl.uniprot.org/core/author | "Nam H.W."xsd:string |
| http://purl.uniprot.org/citations/20570605 | http://purl.uniprot.org/core/author | "Lee M.R."xsd:string |
| http://purl.uniprot.org/citations/20570605 | http://purl.uniprot.org/core/author | "Hinton D.J."xsd:string |
| http://purl.uniprot.org/citations/20570605 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20570605 | http://purl.uniprot.org/core/name | "Neurosci Lett"xsd:string |
| http://purl.uniprot.org/citations/20570605 | http://purl.uniprot.org/core/pages | "277-281"xsd:string |
| http://purl.uniprot.org/citations/20570605 | http://purl.uniprot.org/core/title | "Reduced effect of NMDA glutamate receptor antagonist on ethanol-induced ataxia and striatal glutamate levels in mice lacking ENT1."xsd:string |
| http://purl.uniprot.org/citations/20570605 | http://purl.uniprot.org/core/volume | "479"xsd:string |
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| http://purl.uniprot.org/citations/20570605 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20570605 |
| http://purl.uniprot.org/uniprot/#_E9PZV0-mappedCitation-20570605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20570605 |
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| http://purl.uniprot.org/uniprot/#_E9PXM6-mappedCitation-20570605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20570605 |
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