| http://purl.uniprot.org/citations/20572199 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20572199 | http://www.w3.org/2000/01/rdf-schema#comment | "Because stress represents a major precipitating event for psychiatric disorders, it is important to identify molecular mechanisms that may be altered in vulnerable individuals when exposed to stress. Here, we studied GluR-A(-/-) mice, animals with compromised AMPA receptor signaling, and characterized by a schizophrenic as well as depressive phenotype to investigate changes occurring in response to an acute stress. Wild-type and GluR-A(-/-) mice were exposed to a single immobilization stress and sacrificed immediately after the end of the stress for the analysis of activity regulated genes and of glutamatergic synapse responsiveness. The acute stress produced a marked increase in the hippocampal expression of Arc (activity-regulated cytoskeletal-associated protein) in GluR-A(-/-) , but not in wild-type mice, which was associated with a similar increase of phospho-CaMKII, a partner in the action of Arc. When looking at the glutamatergic response to stress in wild-type animals, we found that stress increased GluR-A phosphorylation on serine831, an effect that was paralleled by a significant increase of the phosphorylation of the main NMDA receptor subunits, that is, NR-1 and NR-2B. Conversely, the stress-induced modulation of NMDA receptor subunits was not observed in GluR-A(-/-) mice. We suggest that enhanced stress responsiveness in GluR-A(-/-) mice may be due, at least in part, to their inability to activate NMDA-mediated glutamatergic neurotransmission, suggesting that the integrity of AMPA/NMDA receptor function may be important for successful coping under stressful conditions."xsd:string |
| http://purl.uniprot.org/citations/20572199 | http://purl.org/dc/terms/identifier | "doi:10.1002/hipo.20817"xsd:string |
| http://purl.uniprot.org/citations/20572199 | http://purl.uniprot.org/core/author | "Sprengel R."xsd:string |
| http://purl.uniprot.org/citations/20572199 | http://purl.uniprot.org/core/author | "Fumagalli F."xsd:string |
| http://purl.uniprot.org/citations/20572199 | http://purl.uniprot.org/core/author | "Gass P."xsd:string |
| http://purl.uniprot.org/citations/20572199 | http://purl.uniprot.org/core/author | "Frasca A."xsd:string |
| http://purl.uniprot.org/citations/20572199 | http://purl.uniprot.org/core/author | "Riva M.A."xsd:string |
| http://purl.uniprot.org/citations/20572199 | http://purl.uniprot.org/core/author | "Racagni G."xsd:string |
| http://purl.uniprot.org/citations/20572199 | http://purl.uniprot.org/core/author | "Vogt M.A."xsd:string |
| http://purl.uniprot.org/citations/20572199 | http://purl.uniprot.org/core/author | "Caffino L."xsd:string |
| http://purl.uniprot.org/citations/20572199 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/20572199 | http://purl.uniprot.org/core/name | "Hippocampus"xsd:string |
| http://purl.uniprot.org/citations/20572199 | http://purl.uniprot.org/core/pages | "1028-1035"xsd:string |
| http://purl.uniprot.org/citations/20572199 | http://purl.uniprot.org/core/title | "AMPA GluR-A receptor subunit mediates hippocampal responsiveness in mice exposed to stress."xsd:string |
| http://purl.uniprot.org/citations/20572199 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/20572199 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20572199 |
| http://purl.uniprot.org/citations/20572199 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20572199 |
| http://purl.uniprot.org/uniprot/#_F6YNQ1-mappedCitation-20572199 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20572199 |
| http://purl.uniprot.org/uniprot/#_C9K0Y3-mappedCitation-20572199 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20572199 |
| http://purl.uniprot.org/uniprot/#_C9K0Y4-mappedCitation-20572199 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20572199 |
| http://purl.uniprot.org/uniprot/#_C9K0Y8-mappedCitation-20572199 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20572199 |
| http://purl.uniprot.org/uniprot/#_Q7TNB5-mappedCitation-20572199 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20572199 |
| http://purl.uniprot.org/uniprot/#_G5CJW6-mappedCitation-20572199 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20572199 |
| http://purl.uniprot.org/uniprot/#_G5CJW7-mappedCitation-20572199 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20572199 |