| http://purl.uniprot.org/citations/20573983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20573983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20573983 | http://www.w3.org/2000/01/rdf-schema#comment | "Caenorhabditis elegans RAB-10 functions in endocytic recycling in polarized cells, regulating basolateral cargo transport in the intestinal epithelia and postsynaptic cargo transport in interneurons. A similar role was found for mammalian Rab10 in MDCK cells, suggesting that a conserved mechanism regulates these related pathways in metazoans. In a yeast two-hybrid screen for binding partners of RAB-10 we identified EHBP-1, a calponin homology domain (CH) protein, whose mammalian homolog Ehbp1 was previously shown to function during endocytic transport of GLUT4 in adipocytes. In vivo we find that EHBP-1-GFP colocalizes with RFP-RAB-10 on endosomal structures of the intestine and interneurons and that ehbp-1 loss-of-function mutants share with rab-10 mutants specific endosome morphology and cargo localization defects. We also show that loss of EHBP-1 disrupts transport of membrane proteins to the plasma membrane of the nonpolarized germline cells, a defect that can be phenocopied by codepletion of RAB-10 and its closest paralog RAB-8. These results indicate that RAB-10 and EHBP-1 function together in many cell types and suggests that there are differences in the level of redundancy among Rab family members in polarized versus nonpolarized cells."xsd:string |
| http://purl.uniprot.org/citations/20573983 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e10-02-0149"xsd:string |
| http://purl.uniprot.org/citations/20573983 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e10-02-0149"xsd:string |
| http://purl.uniprot.org/citations/20573983 | http://purl.uniprot.org/core/author | "Banerjee R."xsd:string |
| http://purl.uniprot.org/citations/20573983 | http://purl.uniprot.org/core/author | "Banerjee R."xsd:string |
| http://purl.uniprot.org/citations/20573983 | http://purl.uniprot.org/core/author | "Shi A."xsd:string |
| http://purl.uniprot.org/citations/20573983 | http://purl.uniprot.org/core/author | "Shi A."xsd:string |
| http://purl.uniprot.org/citations/20573983 | http://purl.uniprot.org/core/author | "Chen C.C."xsd:string |
| http://purl.uniprot.org/citations/20573983 | http://purl.uniprot.org/core/author | "Chen C.C."xsd:string |
| http://purl.uniprot.org/citations/20573983 | http://purl.uniprot.org/core/author | "Grant B.D."xsd:string |
| http://purl.uniprot.org/citations/20573983 | http://purl.uniprot.org/core/author | "Grant B.D."xsd:string |
| http://purl.uniprot.org/citations/20573983 | http://purl.uniprot.org/core/author | "Rongo C."xsd:string |
| http://purl.uniprot.org/citations/20573983 | http://purl.uniprot.org/core/author | "Rongo C."xsd:string |
| http://purl.uniprot.org/citations/20573983 | http://purl.uniprot.org/core/author | "Audhya A."xsd:string |
| http://purl.uniprot.org/citations/20573983 | http://purl.uniprot.org/core/author | "Audhya A."xsd:string |
| http://purl.uniprot.org/citations/20573983 | http://purl.uniprot.org/core/author | "Glodowski D."xsd:string |
| http://purl.uniprot.org/citations/20573983 | http://purl.uniprot.org/core/author | "Glodowski D."xsd:string |
| http://purl.uniprot.org/citations/20573983 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20573983 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20573983 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/20573983 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/20573983 | http://purl.uniprot.org/core/pages | "2930-2943"xsd:string |
| http://purl.uniprot.org/citations/20573983 | http://purl.uniprot.org/core/pages | "2930-2943"xsd:string |