| http://purl.uniprot.org/citations/20573984 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20573984 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20573984 | http://www.w3.org/2000/01/rdf-schema#comment | "CREB (cyclic AMP response element-binding protein) is a stimulus-induced transcription factor that plays pivotal roles in cell survival and proliferation. The transactivation function of CREB is primarily regulated through Ser-133 phosphorylation by cAMP-dependent protein kinase A (PKA) and related kinases. Here we found that homeodomain-interacting protein kinase 2 (HIPK2), a DNA-damage responsive nuclear kinase, is a new CREB kinase for phosphorylation at Ser-271 but not Ser-133, and activates CREB transactivation function including brain-derived neurotrophic factor (BDNF) mRNA expression. Ser-271 to Glu-271 substitution potentiated the CREB transactivation function. ChIP assays in SH-SY5Y neuroblastoma cells demonstrated that CREB Ser-271 phosphorylation by HIPK2 increased recruitment of a transcriptional coactivator CBP (CREB binding protein) without modulation of CREB binding to the BDNF CRE sequence. HIPK2-/-MEF cells were more susceptible to apoptosis induced by etoposide, a DNA-damaging agent, than HIPK2+/+ cells. Etoposide activated CRE-dependent transcription in HIPK2+/+ MEF cells but not in HIPK2-/-cells. HIPK2 knockdown in SH-SY5Y cells decreased etoposide-induced BDNF mRNA expression. These results demonstrate that HIPK2 is a new CREB kinase that regulates CREB-dependent transcription in genotoxic stress."xsd:string |
| http://purl.uniprot.org/citations/20573984 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e10-01-0015"xsd:string |
| http://purl.uniprot.org/citations/20573984 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e10-01-0015"xsd:string |
| http://purl.uniprot.org/citations/20573984 | http://purl.uniprot.org/core/author | "Sakamoto K."xsd:string |
| http://purl.uniprot.org/citations/20573984 | http://purl.uniprot.org/core/author | "Sakamoto K."xsd:string |
| http://purl.uniprot.org/citations/20573984 | http://purl.uniprot.org/core/author | "Iwasaki K."xsd:string |
| http://purl.uniprot.org/citations/20573984 | http://purl.uniprot.org/core/author | "Iwasaki K."xsd:string |
| http://purl.uniprot.org/citations/20573984 | http://purl.uniprot.org/core/author | "Hailemariam K."xsd:string |
| http://purl.uniprot.org/citations/20573984 | http://purl.uniprot.org/core/author | "Hailemariam K."xsd:string |
| http://purl.uniprot.org/citations/20573984 | http://purl.uniprot.org/core/author | "Tsuji Y."xsd:string |
| http://purl.uniprot.org/citations/20573984 | http://purl.uniprot.org/core/author | "Tsuji Y."xsd:string |
| http://purl.uniprot.org/citations/20573984 | http://purl.uniprot.org/core/author | "Ninomiya-Tsuji J."xsd:string |
| http://purl.uniprot.org/citations/20573984 | http://purl.uniprot.org/core/author | "Ninomiya-Tsuji J."xsd:string |
| http://purl.uniprot.org/citations/20573984 | http://purl.uniprot.org/core/author | "Huang B.-W."xsd:string |
| http://purl.uniprot.org/citations/20573984 | http://purl.uniprot.org/core/author | "Huang B.-W."xsd:string |
| http://purl.uniprot.org/citations/20573984 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20573984 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20573984 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/20573984 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/20573984 | http://purl.uniprot.org/core/pages | "2966-2974"xsd:string |
| http://purl.uniprot.org/citations/20573984 | http://purl.uniprot.org/core/pages | "2966-2974"xsd:string |
| http://purl.uniprot.org/citations/20573984 | http://purl.uniprot.org/core/title | "Regulation of genotoxic stress response by homeodomain-interacting protein kinase 2 through phosphorylation of cyclic AMP response element-binding protein at serine 271."xsd:string |
| http://purl.uniprot.org/citations/20573984 | http://purl.uniprot.org/core/title | "Regulation of genotoxic stress response by homeodomain-interacting protein kinase 2 through phosphorylation of cyclic AMP response element-binding protein at serine 271."xsd:string |