| http://purl.uniprot.org/citations/20574000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20574000 | http://www.w3.org/2000/01/rdf-schema#comment | "Antagonists of the type 1 cysteinyl leukotriene receptor (CysLT(1)R) are efficacious for bronchoconstriction in humans with bronchial asthma; however, the clinical response to these drugs is heterogeneous. In particular, how CysLT(1)R expression and function are constitutively regulated in vivo is not known. In this study, we show that a seven-transmembrane receptor, GPR17, negatively regulates the CysLT(1)R-mediated inflammatory cell accumulation in the bronchoalveolar lavage fluid and lung, the levels of IgE and specific IgG1 in serum, and Th2/Th17 cytokine expression in the lung after intranasal sensitization and challenge with the house dust mite (extract of Dermatophagoides farinae [Df]) in mice. Sensitization of naive wild-type recipients with Df-pulsed bone marrow-derived dendritic cells of each genotype or sensitization of each genotype with Df-pulsed wild-type bone marrow-derived dendritic cells and Df challenge revealed markedly increased pulmonary inflammatory and serum IgE responses for GPR17-deficient mice as compared with wild-type mice and reduced responses in the genotypes lacking CysLT(1)R. These findings reveal a constitutive negative regulation of CysLT(1)R functions by GPR17 in both the Ag presentation and downstream phases of allergic pulmonary inflammation."xsd:string |
| http://purl.uniprot.org/citations/20574000 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1001131"xsd:string |
| http://purl.uniprot.org/citations/20574000 | http://purl.uniprot.org/core/author | "Xing W."xsd:string |
| http://purl.uniprot.org/citations/20574000 | http://purl.uniprot.org/core/author | "Maekawa A."xsd:string |
| http://purl.uniprot.org/citations/20574000 | http://purl.uniprot.org/core/author | "Kanaoka Y."xsd:string |
| http://purl.uniprot.org/citations/20574000 | http://purl.uniprot.org/core/author | "Austen K.F."xsd:string |
| http://purl.uniprot.org/citations/20574000 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20574000 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/20574000 | http://purl.uniprot.org/core/pages | "1846-1854"xsd:string |
| http://purl.uniprot.org/citations/20574000 | http://purl.uniprot.org/core/title | "GPR17 regulates immune pulmonary inflammation induced by house dust mites."xsd:string |
| http://purl.uniprot.org/citations/20574000 | http://purl.uniprot.org/core/volume | "185"xsd:string |
| http://purl.uniprot.org/citations/20574000 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20574000 |
| http://purl.uniprot.org/citations/20574000 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20574000 |
| http://purl.uniprot.org/uniprot/Q99JA4#attribution-1C711F0AB2A5A6DD4C55291FB4EBF867 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20574000 |
| http://purl.uniprot.org/uniprot/Q6NS65#attribution-1C711F0AB2A5A6DD4C55291FB4EBF867 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20574000 |
| http://purl.uniprot.org/uniprot/#_Q99JA4-mappedCitation-20574000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20574000 |
| http://purl.uniprot.org/uniprot/#_Q6NS65-mappedCitation-20574000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20574000 |
| http://purl.uniprot.org/uniprot/Q99JA4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20574000 |
| http://purl.uniprot.org/uniprot/Q6NS65 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20574000 |