| http://purl.uniprot.org/citations/20577261 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20577261 | http://www.w3.org/2000/01/rdf-schema#comment | "L-glutamate, the major excitatory neurotransmitter, also has a role in non-neuronal tissues and modulates immune responses. Whether NMDA receptor (NMDAR) signalling is involved in T-cell development is unknown. In this study, we show that mouse thymocytes expressed an array of glutamate receptors, including NMDARs subunits. Sustained calcium (Ca(2+)) signals and caspase-3 activation in thymocytes were induced by interaction with antigen-pulsed dendritic cells (DCs) and were inhibited by NMDAR antagonists MK801 and memantine. NMDARs were transiently activated, triggered the sustained Ca(2+) signal and were corecruited with the PDZ-domain adaptor postsynaptic density (PSD)-95 to thymocyte-DC contact zones. Although T-cell receptor (TCR) activation was sufficient for relocalization of NMDAR and PSD-95 at the contact zone, NMDAR could be activated only in a synaptic context. In these T-DC contacts, thymocyte activation occurred in the absence of exogenous glutamate, indicating that DCs could be a physiological source of glutamate. DCs expressed glutamate, glutamate-specific vesicular glutamate transporters and were capable of fast glutamate release through a Ca(2+)-dependent mechanism. We suggest that glutamate released by DCs could elicit focal responses through NMDAR-signalling in T cells undergoing apoptosis. Thus, synapses between T and DCs could provide a functional platform for coupling TCR activation and NMDAR signalling, which might reflect on T-cell development and modulation of the immune response."xsd:string |
| http://purl.uniprot.org/citations/20577261 | http://purl.org/dc/terms/identifier | "doi:10.1038/cdd.2010.79"xsd:string |
| http://purl.uniprot.org/citations/20577261 | http://purl.uniprot.org/core/author | "Potier M.C."xsd:string |
| http://purl.uniprot.org/citations/20577261 | http://purl.uniprot.org/core/author | "Collingridge G.L."xsd:string |
| http://purl.uniprot.org/citations/20577261 | http://purl.uniprot.org/core/author | "Affaticati P."xsd:string |
| http://purl.uniprot.org/citations/20577261 | http://purl.uniprot.org/core/author | "Gouadon E."xsd:string |
| http://purl.uniprot.org/citations/20577261 | http://purl.uniprot.org/core/author | "Capiod T."xsd:string |
| http://purl.uniprot.org/citations/20577261 | http://purl.uniprot.org/core/author | "Peineau S."xsd:string |
| http://purl.uniprot.org/citations/20577261 | http://purl.uniprot.org/core/author | "Degrouard J."xsd:string |
| http://purl.uniprot.org/citations/20577261 | http://purl.uniprot.org/core/author | "Liblau R."xsd:string |
| http://purl.uniprot.org/citations/20577261 | http://purl.uniprot.org/core/author | "Mignen O."xsd:string |
| http://purl.uniprot.org/citations/20577261 | http://purl.uniprot.org/core/author | "Cohen-Kaminsky S."xsd:string |
| http://purl.uniprot.org/citations/20577261 | http://purl.uniprot.org/core/author | "Jambou F."xsd:string |
| http://purl.uniprot.org/citations/20577261 | http://purl.uniprot.org/core/author | "Klingel-Schmitt I."xsd:string |
| http://purl.uniprot.org/citations/20577261 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/20577261 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/20577261 | http://purl.uniprot.org/core/pages | "99-108"xsd:string |
| http://purl.uniprot.org/citations/20577261 | http://purl.uniprot.org/core/title | "Sustained calcium signalling and caspase-3 activation involve NMDA receptors in thymocytes in contact with dendritic cells."xsd:string |
| http://purl.uniprot.org/citations/20577261 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/20577261 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20577261 |
| http://purl.uniprot.org/citations/20577261 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20577261 |
| http://purl.uniprot.org/uniprot/#_A0A338P713-mappedCitation-20577261 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20577261 |
| http://purl.uniprot.org/uniprot/#_A0A338P746-mappedCitation-20577261 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20577261 |
| http://purl.uniprot.org/uniprot/#_A0A338P7H1-mappedCitation-20577261 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20577261 |