| http://purl.uniprot.org/citations/20584765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20584765 | http://www.w3.org/2000/01/rdf-schema#comment | "Arenaviruses such as Lassa virus (LASV) cause significant morbidity and mortality in endemic areas. Using a glycoprotein (GP) exchange strategy, we have recently developed live-attenuated arenavirus vaccine prototypes (rLCMV/VSVG) based on lymphocytic choriomeningitis virus (LCMV), a close relative of LASV. rLCMV/VSVG induced long-term CD8(+) T cell immunity against wild-type virus challenge and exhibited a stably attenuated phenotype in vivo. Here we elucidated the innate and adaptive immune requirements for the control of rLCMV/VSVG. Infection of RAG(-/-) mice resulted in persisting viral RNA in blood but not in overt viremia. The latter was only found in mice lacking both RAG and IFN type I receptor. Conversely, absence of IFN type II signaling or NK cells on an RAG-deficient background had only minor effects on vaccine virus load or none at all. rLCMV/VSVG infection of wild-type mice induced less type I IFN than did wild-type LCMV, and type I as well as type II IFNs were dispensable for the induction of virus-specific memory CD8 T cells and virus-neutralizing antibodies by rLCMV/VSVG. In conclusion, the adaptive immune systems are essential for elimination of rLCMV/VSVG, and type I but not type II IFN plays a major contributive role in lowering rLCMV/VSVG loads in vivo, attesting to the attenuation profile of the vaccine. Nevertheless, IFNs are not required for the induction of potent vaccine responses. These results provide a better understanding of the immunobiology of rLCMV/VSVG and will contribute to the further development of GP exchange vaccines for combating arenaviral hemorrhagic fevers."xsd:string |
| http://purl.uniprot.org/citations/20584765 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/dxq061"xsd:string |
| http://purl.uniprot.org/citations/20584765 | http://purl.uniprot.org/core/author | "Fernandez M."xsd:string |
| http://purl.uniprot.org/citations/20584765 | http://purl.uniprot.org/core/author | "Suter M."xsd:string |
| http://purl.uniprot.org/citations/20584765 | http://purl.uniprot.org/core/author | "Flatz L."xsd:string |
| http://purl.uniprot.org/citations/20584765 | http://purl.uniprot.org/core/author | "Bergthaler A."xsd:string |
| http://purl.uniprot.org/citations/20584765 | http://purl.uniprot.org/core/author | "Pinschewer D.D."xsd:string |
| http://purl.uniprot.org/citations/20584765 | http://purl.uniprot.org/core/author | "Steinborn R."xsd:string |
| http://purl.uniprot.org/citations/20584765 | http://purl.uniprot.org/core/author | "Horvath E."xsd:string |
| http://purl.uniprot.org/citations/20584765 | http://purl.uniprot.org/core/author | "Lutz H."xsd:string |
| http://purl.uniprot.org/citations/20584765 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20584765 | http://purl.uniprot.org/core/name | "Int Immunol"xsd:string |
| http://purl.uniprot.org/citations/20584765 | http://purl.uniprot.org/core/pages | "749-756"xsd:string |
| http://purl.uniprot.org/citations/20584765 | http://purl.uniprot.org/core/title | "Innate and adaptive immune control of genetically engineered live-attenuated arenavirus vaccine prototypes."xsd:string |
| http://purl.uniprot.org/citations/20584765 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/20584765 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20584765 |
| http://purl.uniprot.org/citations/20584765 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20584765 |
| http://purl.uniprot.org/uniprot/#_P15261-mappedCitation-20584765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20584765 |
| http://purl.uniprot.org/uniprot/#_A0A338P6T9-mappedCitation-20584765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20584765 |
| http://purl.uniprot.org/uniprot/#_A0A338P6X7-mappedCitation-20584765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20584765 |
| http://purl.uniprot.org/uniprot/#_A0A384DVB8-mappedCitation-20584765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20584765 |
| http://purl.uniprot.org/uniprot/#_B0QZX1-mappedCitation-20584765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20584765 |
| http://purl.uniprot.org/uniprot/#_E9PX11-mappedCitation-20584765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20584765 |
| http://purl.uniprot.org/uniprot/#_P34902-mappedCitation-20584765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20584765 |