| http://purl.uniprot.org/citations/20585042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20585042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20585042 | http://www.w3.org/2000/01/rdf-schema#comment | "T-cell ubiquitin ligand-2 (TULA-2) is a recently discovered histidine tyrosine phosphatase thought to be ubiquitously expressed. In this work, we have investigated whether TULA-2 has a key role in platelet glycoprotein VI (GPVI) signaling. This study indicates that TULA-2 is expressed in human and murine platelets and is able to associate with Syk and dephosphorylate it. Ablation of TULA-2 resulted in hyperphosphorylation of Syk and its downstream effector phospholipase C-γ2 as well as enhanced GPVI-mediated platelet functional responses. In addition, shorter bleeding times and a prothrombotic phenotype were observed in mice lacking TULA-2. We therefore propose that TULA-2 is the primary tyrosine phosphatase mediating the dephosphorylation of Syk and thus functions as a negative regulator of GPVI signaling in platelets."xsd:string |
| http://purl.uniprot.org/citations/20585042 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2010-02-268136"xsd:string |
| http://purl.uniprot.org/citations/20585042 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2010-02-268136"xsd:string |
| http://purl.uniprot.org/citations/20585042 | http://purl.uniprot.org/core/author | "Kunapuli S.P."xsd:string |
| http://purl.uniprot.org/citations/20585042 | http://purl.uniprot.org/core/author | "Kunapuli S.P."xsd:string |
| http://purl.uniprot.org/citations/20585042 | http://purl.uniprot.org/core/author | "Tsygankov A.Y."xsd:string |
| http://purl.uniprot.org/citations/20585042 | http://purl.uniprot.org/core/author | "Tsygankov A.Y."xsd:string |
| http://purl.uniprot.org/citations/20585042 | http://purl.uniprot.org/core/author | "Carpino N."xsd:string |
| http://purl.uniprot.org/citations/20585042 | http://purl.uniprot.org/core/author | "Carpino N."xsd:string |
| http://purl.uniprot.org/citations/20585042 | http://purl.uniprot.org/core/author | "Daniel J.L."xsd:string |
| http://purl.uniprot.org/citations/20585042 | http://purl.uniprot.org/core/author | "Daniel J.L."xsd:string |
| http://purl.uniprot.org/citations/20585042 | http://purl.uniprot.org/core/author | "Thomas D.H."xsd:string |
| http://purl.uniprot.org/citations/20585042 | http://purl.uniprot.org/core/author | "Thomas D.H."xsd:string |
| http://purl.uniprot.org/citations/20585042 | http://purl.uniprot.org/core/author | "Dangelmaier C.A."xsd:string |
| http://purl.uniprot.org/citations/20585042 | http://purl.uniprot.org/core/author | "Dangelmaier C.A."xsd:string |
| http://purl.uniprot.org/citations/20585042 | http://purl.uniprot.org/core/author | "Getz T.M."xsd:string |
| http://purl.uniprot.org/citations/20585042 | http://purl.uniprot.org/core/author | "Getz T.M."xsd:string |
| http://purl.uniprot.org/citations/20585042 | http://purl.uniprot.org/core/author | "Newman T.N."xsd:string |
| http://purl.uniprot.org/citations/20585042 | http://purl.uniprot.org/core/author | "Newman T.N."xsd:string |
| http://purl.uniprot.org/citations/20585042 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20585042 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20585042 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/20585042 | http://purl.uniprot.org/core/name | "Blood"xsd:string |