| http://purl.uniprot.org/citations/20587604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20587604 | http://www.w3.org/2000/01/rdf-schema#comment | "Several genome-wide association studies identified the chr15q25.1 region, which includes three nicotinic cholinergic receptor genes (CHRNA5-B4) and the cell proliferation gene (PSMA4), for its association with lung cancer risk in Caucasians. A haplotype and its tagging single nucleotide polymorphisms (SNPs) encompassing six genes from IREB2 to CHRNB4 were most strongly associated with lung cancer risk (OR = 1.3; P < 10(-20)). In order to narrow the region of association and identify potential causal variations, we performed a fine-mapping study using 77 SNPs in a 194 kb segment of the 15q25.1 region in a sample of 448 African-American lung cancer cases and 611 controls. Four regions, two SNPs and two distinct haplotypes from sliding window analyses, were associated with lung cancer. CHRNA5 rs17486278 G had OR = 1.28, 95% CI 1.07-1.54 and P = 0.008, whereas CHRNB4 rs7178270 G had OR = 0.78, 95% CI 0.66-0.94 and P = 0.008 for lung cancer risk. Lung cancer associations remained significant after pack-year adjustment. Rs7178270 decreased lung cancer risk in women but not in men; gender interaction P = 0.009. For two SNPs (rs7168796 A/G and rs7164594 A/G) upstream of PSMA4, lung cancer risks for people with haplotypes GG and AA were reduced compared with those with AG (OR = 0.56, 95% CI 0.38-0.82; P = 0.003 and OR = 0.73, 95% CI 0.59-0.90, P = 0.004, respectively). A four-SNP haplotype spanning CHRNA5 (rs11637635 C, rs17408276 T, rs16969968 G) and CHRNA3 (rs578776 G) was associated with increased lung cancer risk (P = 0.002). The identified regions contain SNPs predicted to affect gene regulation. There are multiple lung cancer risk loci in the 15q25.1 region in African-Americans."xsd:string |
| http://purl.uniprot.org/citations/20587604 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddq268"xsd:string |
| http://purl.uniprot.org/citations/20587604 | http://purl.uniprot.org/core/author | "Xiao Y."xsd:string |
| http://purl.uniprot.org/citations/20587604 | http://purl.uniprot.org/core/author | "Smirnov I.V."xsd:string |
| http://purl.uniprot.org/citations/20587604 | http://purl.uniprot.org/core/author | "Seldin M.F."xsd:string |
| http://purl.uniprot.org/citations/20587604 | http://purl.uniprot.org/core/author | "Chang J.S."xsd:string |
| http://purl.uniprot.org/citations/20587604 | http://purl.uniprot.org/core/author | "Rice T."xsd:string |
| http://purl.uniprot.org/citations/20587604 | http://purl.uniprot.org/core/author | "Kelsey K.T."xsd:string |
| http://purl.uniprot.org/citations/20587604 | http://purl.uniprot.org/core/author | "Wiencke J.K."xsd:string |
| http://purl.uniprot.org/citations/20587604 | http://purl.uniprot.org/core/author | "Wrensch M.R."xsd:string |
| http://purl.uniprot.org/citations/20587604 | http://purl.uniprot.org/core/author | "Hansen H.M."xsd:string |
| http://purl.uniprot.org/citations/20587604 | http://purl.uniprot.org/core/author | "Patoka J."xsd:string |
| http://purl.uniprot.org/citations/20587604 | http://purl.uniprot.org/core/author | "Bracci P.M."xsd:string |
| http://purl.uniprot.org/citations/20587604 | http://purl.uniprot.org/core/author | "Sison J.D."xsd:string |
| http://purl.uniprot.org/citations/20587604 | http://purl.uniprot.org/core/author | "Quesenberry C.P."xsd:string |
| http://purl.uniprot.org/citations/20587604 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20587604 | http://purl.uniprot.org/core/name | "Hum Mol Genet"xsd:string |
| http://purl.uniprot.org/citations/20587604 | http://purl.uniprot.org/core/pages | "3652-3661"xsd:string |
| http://purl.uniprot.org/citations/20587604 | http://purl.uniprot.org/core/title | "Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans."xsd:string |
| http://purl.uniprot.org/citations/20587604 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/20587604 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20587604 |
| http://purl.uniprot.org/citations/20587604 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20587604 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DGM4-mappedCitation-20587604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20587604 |
| http://purl.uniprot.org/uniprot/#_B2RDG0-mappedCitation-20587604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20587604 |