| http://purl.uniprot.org/citations/20588004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20588004 | http://www.w3.org/2000/01/rdf-schema#comment | "Allergen exposure can induce an early innate immune response; however, the mechanism by which this occurs has not been addressed. In this report, we demonstrate a role for the active serine proteases in German cockroach (GC) feces (frass) and protease-activated receptor (PAR)-2 in modulating the innate immune response. A single exposure of GC frass induced inflammatory cytokine production and cellular infiltration in the airways of mice. In comparison, exposure to protease-depleted GC frass resulted in diminution of inflammatory cytokine production and airway neutrophilia, but had no effect on macrophage infiltration. Selective activation of PAR-2 confirmed that PAR-2 was sufficient to induce airway inflammation. Exposure of GC frass to PAR-2-deficient mice led to decreased immune responses to GC frass compared to wild-type mice. Using the macrophage as an early marker of the innate immune response, we found that GC frass induced significant release of tumor necrosis factor-alpha from primary alveolar macrophages. This effect was dependent on the intrinsic proteases in GC frass. We confirmed GC frass-induced cytokine expression was mediated by activation of NF-kappaB and ERK in a macrophage cell line. Collectively, these data suggest a central role for GC frass protease-PAR-2 activation in regulating the innate immune response through the activation of alveolar macrophages. Understanding the potential role of protease-PAR-2 activation as a danger signal or adjuvant could yield attractive therapeutic targets."xsd:string |
| http://purl.uniprot.org/citations/20588004 | http://purl.org/dc/terms/identifier | "doi:10.1159/000317195"xsd:string |
| http://purl.uniprot.org/citations/20588004 | http://purl.uniprot.org/core/author | "Zhou P."xsd:string |
| http://purl.uniprot.org/citations/20588004 | http://purl.uniprot.org/core/author | "Page K."xsd:string |
| http://purl.uniprot.org/citations/20588004 | http://purl.uniprot.org/core/author | "Ledford J.R."xsd:string |
| http://purl.uniprot.org/citations/20588004 | http://purl.uniprot.org/core/author | "Day S.B."xsd:string |
| http://purl.uniprot.org/citations/20588004 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20588004 | http://purl.uniprot.org/core/name | "J Innate Immun"xsd:string |
| http://purl.uniprot.org/citations/20588004 | http://purl.uniprot.org/core/pages | "495-504"xsd:string |
| http://purl.uniprot.org/citations/20588004 | http://purl.uniprot.org/core/title | "German cockroach frass proteases modulate the innate immune response via activation of protease-activated receptor-2."xsd:string |
| http://purl.uniprot.org/citations/20588004 | http://purl.uniprot.org/core/volume | "2"xsd:string |
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