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http://purl.uniprot.org/citations/20591152http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20591152http://www.w3.org/2000/01/rdf-schema#comment"

Background

Wnt factors control cell differentiation through semi-independent molecular cascades known as the beta-catenin-dependent (canonical) and -independent (non-canonical) Wnt signalling pathways. Genetic and epigenetic alteration of components of the canonical Wnt signalling pathway is one of the primary mechanisms underlying colon cancer. Despite increasing evidence of the role of the non-canonical pathways in tumourigenesis, however, the underlying molecular mechanisms are poorly understood.

Results

Here we report that the receptor tyrosine kinase-like orphan receptor 2 (ROR2), a transmembrane receptor for Wnt factors that activates non-canonical pathways, is frequently repressed by aberrant promoter hypermethylation in human colon cancer cell lines and primary tumours. By restoring ROR2 activity in colon cancer cells harbouring ROR2 promoter hypermethylation, we show that the role of ROR2 in colon cancer cells is mediated, at least in part, by canonical Wnt and that its epigenetic-dependent loss can be pro-tumourigenic.

Conclusions

Our data show the importance of epigenetic alterations of ROR2 in colon cancer, highlighting the close interconnection between canonical and non-canonical Wnt signalling pathways in this type of tumour."xsd:string
http://purl.uniprot.org/citations/20591152http://purl.org/dc/terms/identifier"doi:10.1186/1476-4598-9-170"xsd:string
http://purl.uniprot.org/citations/20591152http://purl.uniprot.org/core/author"Lopez-Otin C."xsd:string
http://purl.uniprot.org/citations/20591152http://purl.uniprot.org/core/author"Sanchez L."xsd:string
http://purl.uniprot.org/citations/20591152http://purl.uniprot.org/core/author"Munoz A."xsd:string
http://purl.uniprot.org/citations/20591152http://purl.uniprot.org/core/author"Moncada-Pazos A."xsd:string
http://purl.uniprot.org/citations/20591152http://purl.uniprot.org/core/author"Calvanese V."xsd:string
http://purl.uniprot.org/citations/20591152http://purl.uniprot.org/core/author"Obaya A.J."xsd:string
http://purl.uniprot.org/citations/20591152http://purl.uniprot.org/core/author"Fernandez A.F."xsd:string
http://purl.uniprot.org/citations/20591152http://purl.uniprot.org/core/author"Lara E."xsd:string
http://purl.uniprot.org/citations/20591152http://purl.uniprot.org/core/author"Astudillo A."xsd:string
http://purl.uniprot.org/citations/20591152http://purl.uniprot.org/core/author"Esteller M."xsd:string
http://purl.uniprot.org/citations/20591152http://purl.uniprot.org/core/author"Fraga M.F."xsd:string
http://purl.uniprot.org/citations/20591152http://purl.uniprot.org/core/author"Gonzalez-Sancho J.M."xsd:string
http://purl.uniprot.org/citations/20591152http://purl.uniprot.org/core/author"Huidobro C."xsd:string
http://purl.uniprot.org/citations/20591152http://purl.uniprot.org/core/author"Aguilera O."xsd:string
http://purl.uniprot.org/citations/20591152http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20591152http://purl.uniprot.org/core/name"Mol Cancer"xsd:string
http://purl.uniprot.org/citations/20591152http://purl.uniprot.org/core/pages"170"xsd:string
http://purl.uniprot.org/citations/20591152http://purl.uniprot.org/core/title"Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer."xsd:string
http://purl.uniprot.org/citations/20591152http://purl.uniprot.org/core/volume"9"xsd:string
http://purl.uniprot.org/citations/20591152http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20591152
http://purl.uniprot.org/citations/20591152http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20591152
http://purl.uniprot.org/uniprot/#_A1L4F5-mappedCitation-20591152http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20591152
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