| http://purl.uniprot.org/citations/20591825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20591825 | http://www.w3.org/2000/01/rdf-schema#comment | "Wilms' tumour suppressor gene, WT1, is mutated/deleted in approximately 15% of Wilms' tumours, highly expressed in the majority of other cancers and is essential for normal embryonic development. The gene encodes multiple isoforms of a zinc-finger (ZF) protein with diverse cellular functions, in particular participating in both transcriptional and post-transcriptional gene regulation. Physical interactions of other cellular proteins with WT1 are known to modulate its function. However, despite the isolation of several WT1-binding proteins, the mechanisms involved in regulating WT1 activities are not clearly understood. In this study, we report the identification of the Krüppel-like ZF protein, ZNF224, as a novel human WT1-associating protein and demonstrate that ZNF224 and its isoform ZNF255 show a specific pattern of interaction with the WT1 splicing variants WT1(-KTS) and WT1(+KTS). These interactions occur in different subcellular compartments and are devoted to control different cellular pathways. The nuclear interaction between ZNF224 and WT1(-KTS) results in an increase in trascriptional activation mediated by WT1, implying that ZNF224 acts as a co-regulator of WT1, whereas, on the contrary, the results obtained for ZNF255 suggest a role for this protein in RNA processing together with WT1. Moreover, our data give the first functional information about the involvement of ZNF255 in a specific molecular pathway, RNA maturation and processing."xsd:string |
| http://purl.uniprot.org/citations/20591825 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddq270"xsd:string |
| http://purl.uniprot.org/citations/20591825 | http://purl.uniprot.org/core/author | "Izzo P."xsd:string |
| http://purl.uniprot.org/citations/20591825 | http://purl.uniprot.org/core/author | "Costanzo P."xsd:string |
| http://purl.uniprot.org/citations/20591825 | http://purl.uniprot.org/core/author | "Miles C."xsd:string |
| http://purl.uniprot.org/citations/20591825 | http://purl.uniprot.org/core/author | "Florio F."xsd:string |
| http://purl.uniprot.org/citations/20591825 | http://purl.uniprot.org/core/author | "Cesaro E."xsd:string |
| http://purl.uniprot.org/citations/20591825 | http://purl.uniprot.org/core/author | "Montano G."xsd:string |
| http://purl.uniprot.org/citations/20591825 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20591825 | http://purl.uniprot.org/core/name | "Hum Mol Genet"xsd:string |
| http://purl.uniprot.org/citations/20591825 | http://purl.uniprot.org/core/pages | "3544-3556"xsd:string |
| http://purl.uniprot.org/citations/20591825 | http://purl.uniprot.org/core/title | "Biochemical and functional interaction between ZNF224 and ZNF255, two members of the Kruppel-like zinc-finger protein family and WT1 protein isoforms."xsd:string |
| http://purl.uniprot.org/citations/20591825 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/20591825 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20591825 |
| http://purl.uniprot.org/citations/20591825 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20591825 |
| http://purl.uniprot.org/uniprot/#_A0A0H5AUY0-mappedCitation-20591825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20591825 |
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| http://purl.uniprot.org/uniprot/#_A0A481V744-mappedCitation-20591825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20591825 |
| http://purl.uniprot.org/uniprot/#_A8K8Y5-mappedCitation-20591825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20591825 |
| http://purl.uniprot.org/uniprot/#_A8MN20-mappedCitation-20591825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20591825 |
| http://purl.uniprot.org/uniprot/#_P19544-mappedCitation-20591825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20591825 |
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| http://purl.uniprot.org/uniprot/#_Q9HCA8-mappedCitation-20591825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20591825 |