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http://purl.uniprot.org/citations/20591987http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20591987http://www.w3.org/2000/01/rdf-schema#comment"

Background

Association of the HLA-DRB1*1501 allele with multiple sclerosis is well established, but its association with neuromyelitis optica has only been evaluated in small populations.

Methods

We performed a case-control genetic association study to evaluate the association of HLA-DRB1*1501 with neuromyelitis optica. The single nucleotide polymorphism rs3135388, which tags HLA-DRB1*1501, was genotyped in 164 patients with neuromyelitis optica, 220 patients with multiple sclerosis and 959 controls matched for age, gender and ethnicity. Genotyping for rs3135388 was performed by Taqman-based 5' nuclease assay.

Results

Rs3135388*A was positively associated with multiple sclerosis (OR = 3.93; 95% CI = 2.58-5.97, p = 1.18 x 10(-09)) but negatively associated with NMO (OR = 0.57; 95% CI = 0.36-0.91, p = 0.01).

Conclusions

Multiple sclerosis and neuromyelitis optica differ in their associations with DRB1*1501."xsd:string
http://purl.uniprot.org/citations/20591987http://purl.org/dc/terms/identifier"doi:10.1177/1352458510374340"xsd:string
http://purl.uniprot.org/citations/20591987http://purl.uniprot.org/core/author"Cross A."xsd:string
http://purl.uniprot.org/citations/20591987http://purl.uniprot.org/core/author"Parry G."xsd:string
http://purl.uniprot.org/citations/20591987http://purl.uniprot.org/core/author"Jacob A."xsd:string
http://purl.uniprot.org/citations/20591987http://purl.uniprot.org/core/author"Piccio L."xsd:string
http://purl.uniprot.org/citations/20591987http://purl.uniprot.org/core/author"Atkinson E.J."xsd:string
http://purl.uniprot.org/citations/20591987http://purl.uniprot.org/core/author"Lang W."xsd:string
http://purl.uniprot.org/citations/20591987http://purl.uniprot.org/core/author"Boggild M."xsd:string
http://purl.uniprot.org/citations/20591987http://purl.uniprot.org/core/author"Kristoferitsch W."xsd:string
http://purl.uniprot.org/citations/20591987http://purl.uniprot.org/core/author"Kingsbury D.J."xsd:string
http://purl.uniprot.org/citations/20591987http://purl.uniprot.org/core/author"Scott T."xsd:string
http://purl.uniprot.org/citations/20591987http://purl.uniprot.org/core/author"Schaefer-Klein J."xsd:string
http://purl.uniprot.org/citations/20591987http://purl.uniprot.org/core/author"Weinshenker B.G."xsd:string
http://purl.uniprot.org/citations/20591987http://purl.uniprot.org/core/author"Kantarci O.H."xsd:string
http://purl.uniprot.org/citations/20591987http://purl.uniprot.org/core/author"Barreira A.A."xsd:string
http://purl.uniprot.org/citations/20591987http://purl.uniprot.org/core/author"Brum D.G."xsd:string
http://purl.uniprot.org/citations/20591987http://purl.uniprot.org/core/author"Pardo G."xsd:string
http://purl.uniprot.org/citations/20591987http://purl.uniprot.org/core/author"Paul F."xsd:string
http://purl.uniprot.org/citations/20591987http://purl.uniprot.org/core/author"Matiello M."xsd:string
http://purl.uniprot.org/citations/20591987http://purl.uniprot.org/core/author"Jarius S."xsd:string
http://purl.uniprot.org/citations/20591987http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20591987http://purl.uniprot.org/core/name"Mult Scler"xsd:string
http://purl.uniprot.org/citations/20591987http://purl.uniprot.org/core/pages"981-984"xsd:string