| http://purl.uniprot.org/citations/20595632 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20595632 | http://www.w3.org/2000/01/rdf-schema#comment | "NOD-like receptors (NLRs) and caspase-1 are critical components of innate immunity, yet their over-activation has been linked to a long list of microbial and inflammatory diseases, including anthrax. The Bacillus anthracis lethal toxin (LT) has been shown to activate the NLR Nalp1b and caspase-1 and to induce many symptoms of the anthrax disease in susceptible murine strains. In this study we tested whether it is possible to prevent LT-mediated disease by pharmacological inhibition of caspase-1. We found that caspase-1 and proteasome inhibitors blocked LT-mediated caspase-1 activation and cytolysis of LT-sensitive (Fischer and Brown-Norway) rat macrophages. The proteasome inhibitor NPI-0052 also prevented disease progression and death in susceptible Fischer rats and increased survival in BALB/c mice after LT challenge. In addition, NPI-0052 blocked rapid disease progression and death in susceptible Fischer rats and BALB/c mice challenged with LT. In contrast, Lewis rats, which harbor LT-resistant macrophages, showed no signs of caspase-1 activation after LT injection and did not exhibit rapid disease progression. Taken together, our findings indicate that caspase-1 activation is critical for rapid disease progression in rodents challenged with LT. Our studies indicate that pharmacological inhibition of NLR signaling and caspase-1 can be used to treat inflammatory diseases."xsd:string |
| http://purl.uniprot.org/citations/20595632 | http://purl.org/dc/terms/identifier | "doi:10.2353/ajpath.2010.090828"xsd:string |
| http://purl.uniprot.org/citations/20595632 | http://purl.uniprot.org/core/author | "Casadevall A."xsd:string |
| http://purl.uniprot.org/citations/20595632 | http://purl.uniprot.org/core/author | "Rivera J."xsd:string |
| http://purl.uniprot.org/citations/20595632 | http://purl.uniprot.org/core/author | "Brojatsch J."xsd:string |
| http://purl.uniprot.org/citations/20595632 | http://purl.uniprot.org/core/author | "Palladino M.A."xsd:string |
| http://purl.uniprot.org/citations/20595632 | http://purl.uniprot.org/core/author | "Goldman D.L."xsd:string |
| http://purl.uniprot.org/citations/20595632 | http://purl.uniprot.org/core/author | "Goldberg M.F."xsd:string |
| http://purl.uniprot.org/citations/20595632 | http://purl.uniprot.org/core/author | "Muehlbauer S.M."xsd:string |
| http://purl.uniprot.org/citations/20595632 | http://purl.uniprot.org/core/author | "Jacobson L.S."xsd:string |
| http://purl.uniprot.org/citations/20595632 | http://purl.uniprot.org/core/author | "Lima H. Jr."xsd:string |
| http://purl.uniprot.org/citations/20595632 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20595632 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/20595632 | http://purl.uniprot.org/core/pages | "735-743"xsd:string |
| http://purl.uniprot.org/citations/20595632 | http://purl.uniprot.org/core/title | "Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin."xsd:string |
| http://purl.uniprot.org/citations/20595632 | http://purl.uniprot.org/core/volume | "177"xsd:string |
| http://purl.uniprot.org/citations/20595632 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20595632 |
| http://purl.uniprot.org/citations/20595632 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20595632 |
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| http://purl.uniprot.org/uniprot/A6KQJ8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20595632 |