| http://purl.uniprot.org/citations/20596629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20596629 | http://www.w3.org/2000/01/rdf-schema#comment | "WIF-1 is a negative regulator of the Wnt-signaling pathway that may have important implications for tumorigenesis. Microarray analysis of whole genome expression in mesothelioma tissue revealed down-regulation of 491 genes and up-regulation of 167 genes involved mainly in Jak-STAT signaling (8 genes), MAPK signaling (16 genes) and Wnt signaling (13 genes) pathways. Of these, WIF-1 gene was down-regulated in mesothelioma 72-fold compared to normal tissue. We also analyzed WIF-1 and SFRPs promoter methylations in 46 mesothelioma tissues, 8 mesothelioma cell lines by methylation-specific polymerase chain reaction (MSP). WIF-1 promoter methylation was observed in 34 of 46 mesothelioma tissues (73.9%) and in all 8 mesothelioma cell lines. SFRP1, 2 and 4 promoter methylation was observed in 21 of 37 (56.8%), 26 of 42 (61.9%) and 17 of 36 (47.2%) mesothelioma tissues, respectively. Promoter methylation of any WIF-1 and/or SFRP genes was observed in 44 of 46 (95.6%) mesothelioma tissues. The treatment of mesothelioma cell lines with 5-aza-2'-deoxycytidine (5-aza-2dC) showed WIF-1 promoter methylation recovery followed by restoration of WIF-1 expression in 6 of 8 mesothelioma cell lines. The cytoplasmic expression of beta-catenin was observed in 38 of 43 cases of mesothelioma without any nuclear reactivity. The eight mesothelioma cell lines and 27 cases of mesothelioma examined showed no mutation in exon 3 of beta-catenin suggesting no alteration of canonical Wnt signaling pathway. Our data suggest that WIF-1 promoter methylation is a common event in mesothelioma."xsd:string |
| http://purl.uniprot.org/citations/20596629 | http://purl.org/dc/terms/identifier | "doi:10.3892/or_00000875"xsd:string |
| http://purl.uniprot.org/citations/20596629 | http://purl.uniprot.org/core/author | "Kohno H."xsd:string |
| http://purl.uniprot.org/citations/20596629 | http://purl.uniprot.org/core/author | "Kohno N."xsd:string |
| http://purl.uniprot.org/citations/20596629 | http://purl.uniprot.org/core/author | "Hattori N."xsd:string |
| http://purl.uniprot.org/citations/20596629 | http://purl.uniprot.org/core/author | "Takeshima Y."xsd:string |
| http://purl.uniprot.org/citations/20596629 | http://purl.uniprot.org/core/author | "Inai K."xsd:string |
| http://purl.uniprot.org/citations/20596629 | http://purl.uniprot.org/core/author | "Amatya V.J."xsd:string |
| http://purl.uniprot.org/citations/20596629 | http://purl.uniprot.org/core/author | "Kushitani K."xsd:string |
| http://purl.uniprot.org/citations/20596629 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20596629 | http://purl.uniprot.org/core/name | "Oncol Rep"xsd:string |
| http://purl.uniprot.org/citations/20596629 | http://purl.uniprot.org/core/pages | "423-431"xsd:string |
| http://purl.uniprot.org/citations/20596629 | http://purl.uniprot.org/core/title | "Aberrant promoter methylation of WIF-1 and SFRP1, 2, 4 genes in mesothelioma."xsd:string |
| http://purl.uniprot.org/citations/20596629 | http://purl.uniprot.org/core/volume | "24"xsd:string |
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