| http://purl.uniprot.org/citations/20599664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20599664 | http://www.w3.org/2000/01/rdf-schema#comment | "The muscle ankyrin repeat protein (MARP) family member Ankrd1/CARP is a part of the titin-mechanosensory signaling complex in the sarcomere and in response to stretch it translocates to the nucleus where it participates in the regulation of cardiac genes as a transcriptional co-repressor. Several studies have focused on its structural role in muscle, but its regulatory role is still poorly understood. To gain more insight into the regulatory function of Ankrd1/CARP we searched for transcription factors that could interact and modulate its activity. Using protein array methodology we identified the tumor suppressor protein p53 as an Ankrd1/CARP interacting partner and confirmed their interaction both in vivo and in vitro. We demonstrate a novel role for Ankrd1/CARP as a transcriptional co-activator, moderately up regulating p53 activity. Furthermore, we show that p53 operates as an upstream effector of Ankrd1/CARP, by up regulating the proximal ANKRD1 promoter. Our findings suggest that, besides acting as a transcriptional co-repressor, Ankrd1/CARP could have a stimulatory effect on gene expression in cultured skeletal muscle cells. It is probable that Ankrd1/CARP has a role in the propagation of signals initiated by myogenic regulatory factors (MRFs) during myogenesis."xsd:string |
| http://purl.uniprot.org/citations/20599664 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.abb.2010.06.029"xsd:string |
| http://purl.uniprot.org/citations/20599664 | http://purl.uniprot.org/core/author | "Faulkner G."xsd:string |
| http://purl.uniprot.org/citations/20599664 | http://purl.uniprot.org/core/author | "Belgrano A."xsd:string |
| http://purl.uniprot.org/citations/20599664 | http://purl.uniprot.org/core/author | "Kojic S."xsd:string |
| http://purl.uniprot.org/citations/20599664 | http://purl.uniprot.org/core/author | "Rakicevic L."xsd:string |
| http://purl.uniprot.org/citations/20599664 | http://purl.uniprot.org/core/author | "Divac A."xsd:string |
| http://purl.uniprot.org/citations/20599664 | http://purl.uniprot.org/core/author | "Stankovic M."xsd:string |
| http://purl.uniprot.org/citations/20599664 | http://purl.uniprot.org/core/author | "Nestorovic A."xsd:string |
| http://purl.uniprot.org/citations/20599664 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20599664 | http://purl.uniprot.org/core/name | "Arch Biochem Biophys"xsd:string |
| http://purl.uniprot.org/citations/20599664 | http://purl.uniprot.org/core/pages | "60-67"xsd:string |
| http://purl.uniprot.org/citations/20599664 | http://purl.uniprot.org/core/title | "A novel role for cardiac ankyrin repeat protein Ankrd1/CARP as a co-activator of the p53 tumor suppressor protein."xsd:string |
| http://purl.uniprot.org/citations/20599664 | http://purl.uniprot.org/core/volume | "502"xsd:string |
| http://purl.uniprot.org/citations/20599664 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20599664 |
| http://purl.uniprot.org/citations/20599664 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20599664 |
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