| http://purl.uniprot.org/citations/20599891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20599891 | http://www.w3.org/2000/01/rdf-schema#comment | "Transmembrane adhesion receptors, such as integrins, mediate cell adhesion by interacting with intracellular proteins that connect to the cytoskeleton. Talin, one such linker protein, is essential to connect extracellular matrix-bound integrins to the cytoskeleton. Talin can connect to the cytoskeleton either directly, through its actin-binding motifs, or indirectly, by recruiting other actin-binding proteins. Talin's carboxy-terminal end contains a well-characterized actin-binding domain (ABD). We tested the role of the C-terminal ABD of talin in integrin function in Drosophila. We found that introduction of mutations that reduced actin binding in vitro into the isolated C-terminal Talin-ABD impaired actin binding in vivo. Moreover, when engineered into full-length talin, these mutations disrupted a subset of integrin-mediated adhesion-dependent developmental events. Specifically, morphogenetic processes that involve dynamic, short-term integrin-mediated adhesion were particularly sensitive to impaired function of the C-terminal Talin-ABD. We propose that during development talin connects integrins to the cytoskeleton in distinct ways in different types of integrin-mediated adhesion: directly in transient adhesions and indirectly in stable long-lasting adhesions. Our results provide insight into how a similar array of molecular components can contribute to diverse adhesive processes throughout development."xsd:string |
| http://purl.uniprot.org/citations/20599891 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2010.06.027"xsd:string |
| http://purl.uniprot.org/citations/20599891 | http://purl.uniprot.org/core/author | "Yuan L."xsd:string |
| http://purl.uniprot.org/citations/20599891 | http://purl.uniprot.org/core/author | "Tanentzapf G."xsd:string |
| http://purl.uniprot.org/citations/20599891 | http://purl.uniprot.org/core/author | "Ellis S.J."xsd:string |
| http://purl.uniprot.org/citations/20599891 | http://purl.uniprot.org/core/author | "Cheung T.Y."xsd:string |
| http://purl.uniprot.org/citations/20599891 | http://purl.uniprot.org/core/author | "Fairchild M.J."xsd:string |
| http://purl.uniprot.org/citations/20599891 | http://purl.uniprot.org/core/author | "Franco-Cea A."xsd:string |
| http://purl.uniprot.org/citations/20599891 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20599891 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/20599891 | http://purl.uniprot.org/core/pages | "64-77"xsd:string |
| http://purl.uniprot.org/citations/20599891 | http://purl.uniprot.org/core/title | "Distinct developmental roles for direct and indirect talin-mediated linkage to actin."xsd:string |
| http://purl.uniprot.org/citations/20599891 | http://purl.uniprot.org/core/volume | "345"xsd:string |
| http://purl.uniprot.org/citations/20599891 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20599891 |
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