| http://purl.uniprot.org/citations/20600463 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20600463 | http://www.w3.org/2000/01/rdf-schema#comment | "The primary objective of the present study was to examine whether a combination of parent-child DRD4 genotypes results in more informative biomarkers of oppositional, separation anxiety, and repetitive behaviors in children with autism spectrum disorder (ASD). Based on prior research indicating the 7-repeat allele as a potential risk variant, participants were sorted into one of four combinations of parent-child genotypes. Owing to the possibility of parent-of-origin effects, analyses were conducted separately for mother-child (MC) and father-child (FC) dyads. Mothers completed a validated DSM-IV-referenced rating scale. Partial eta-squared (ηp(2)) was used to determine the magnitude of group differences: 0.01-0.06=small, 0.06-0.14=moderate, and >0.14=large. Analyses indicated that children in MC dyads with matched genotypes had the least (7-/7-) and most (7+/7+) severe mother-rated oppositional-defiant (ηp(2)=0.11) and separation anxiety (ηp(2)=0.19) symptoms. Conversely, youths in FC dyads with matched genotypes had the least (7-/7-) and most (7+/7+) severe obsessive-compulsive behaviors (ηp(2)=0.19) and tics (ηp(2)=0.18). Youths whose parents were both noncarriers had less severe tics than peers with at least one parental carrier, and the effect size was large (ηp(2)=0.16). There was little evidence that noncarrier children were rated more severely by mothers who were carriers versus noncarriers. Transmission Disequilibrium Test analyses provided preliminary evidence for undertransmission of the 2-repeat allele in youths with more severe tics (p=0.02). Parent genotype may be helpful in constructing prognostic biomarkers for behavioral disturbances in ASD; however, findings are tentative pending replication with larger, independent samples."xsd:string |
| http://purl.uniprot.org/citations/20600463 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.pnpbp.2010.06.019"xsd:string |
| http://purl.uniprot.org/citations/20600463 | http://purl.uniprot.org/core/author | "Xu W."xsd:string |
| http://purl.uniprot.org/citations/20600463 | http://purl.uniprot.org/core/author | "Hatchwell E."xsd:string |
| http://purl.uniprot.org/citations/20600463 | http://purl.uniprot.org/core/author | "Mendell N.R."xsd:string |
| http://purl.uniprot.org/citations/20600463 | http://purl.uniprot.org/core/author | "Olvet D.M."xsd:string |
| http://purl.uniprot.org/citations/20600463 | http://purl.uniprot.org/core/author | "DeVincent C.J."xsd:string |
| http://purl.uniprot.org/citations/20600463 | http://purl.uniprot.org/core/author | "Gadow K.D."xsd:string |
| http://purl.uniprot.org/citations/20600463 | http://purl.uniprot.org/core/author | "Finch S.J."xsd:string |
| http://purl.uniprot.org/citations/20600463 | http://purl.uniprot.org/core/author | "Pisarevskaya V."xsd:string |
| http://purl.uniprot.org/citations/20600463 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20600463 | http://purl.uniprot.org/core/name | "Prog Neuropsychopharmacol Biol Psychiatry"xsd:string |
| http://purl.uniprot.org/citations/20600463 | http://purl.uniprot.org/core/pages | "1208-1214"xsd:string |
| http://purl.uniprot.org/citations/20600463 | http://purl.uniprot.org/core/title | "Parent-child DRD4 genotype as a potential biomarker for oppositional, anxiety, and repetitive behaviors in children with autism spectrum disorder."xsd:string |
| http://purl.uniprot.org/citations/20600463 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/20600463 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20600463 |
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