| http://purl.uniprot.org/citations/20600640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20600640 | http://www.w3.org/2000/01/rdf-schema#comment | "Functional recovery following facial nerve injury is poor. Neuromuscular junctions (NMJs) are "bridged" by terminal Schwann cells and numerous regenerating axonal sprouts. We have shown that this poly-innervation of NMJs can be reduced by manual stimulation (MS) with restoration of whisking function. In addition, we have recently reported that insulin-like growth factor-1 (IGF-1) is required to mediate the beneficial effects of MS. Here we extend our findings to brain derived neurotrophic factor (BDNF). We then examined the effect of MS after facial-facial anastomosis (FFA) in heterozygous mice deficient in BDNF (BDNF(+/-)) or in its receptor TrkB (TrkB(+/-)). We quantified vibrissal motor performance and the percentage of NMJ bridged by S100-positive terminal Schwann cells. In intact BDNF(+/-) or TrkB(+/-) mice and their wild type (WT) littermates, there were no differences in vibrissal whisking nor in the percentage of bridged NMJ (0% in each genotype). After FFA and handling alone (i.e. no MS) in WT animals, vibrissal whisking amplitude was reduced (60% lower than intact) and the percentage of bridged NMJ increased (27% more than intact). MS improved both the amplitude of vibrissal whisking (not significantly different from intact) and the percentage of bridged NMJ (11% more than intact). After FFA and handling in BDNF(+/-) or TrkB(+/-) mice, whisking amplitude was again reduced (53% and 60% lower than intact) and proportion of bridged NMJ increased (24% and 29% more than intact). However, MS failed to improve outcome in both heterozygous strains (whisking amplitude 55% and 58% lower than intact; proportion of bridged NMJ 27% and 18% more than intact). We conclude that BDNF and TRkB are required to mediate the effects of MS on target muscle reinnervation and recovery of whisking function."xsd:string |
| http://purl.uniprot.org/citations/20600640 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuroscience.2010.06.053"xsd:string |
| http://purl.uniprot.org/citations/20600640 | http://purl.uniprot.org/core/author | "Irintchev A."xsd:string |
| http://purl.uniprot.org/citations/20600640 | http://purl.uniprot.org/core/author | "Fries J.W."xsd:string |
| http://purl.uniprot.org/citations/20600640 | http://purl.uniprot.org/core/author | "Dunlop S.A."xsd:string |
| http://purl.uniprot.org/citations/20600640 | http://purl.uniprot.org/core/author | "Angelov D.N."xsd:string |
| http://purl.uniprot.org/citations/20600640 | http://purl.uniprot.org/core/author | "Skouras E."xsd:string |
| http://purl.uniprot.org/citations/20600640 | http://purl.uniprot.org/core/author | "Ankerne J."xsd:string |
| http://purl.uniprot.org/citations/20600640 | http://purl.uniprot.org/core/author | "Grosheva M."xsd:string |
| http://purl.uniprot.org/citations/20600640 | http://purl.uniprot.org/core/author | "Hubbers C.U."xsd:string |
| http://purl.uniprot.org/citations/20600640 | http://purl.uniprot.org/core/author | "Kiryakova S."xsd:string |
| http://purl.uniprot.org/citations/20600640 | http://purl.uniprot.org/core/author | "Sinis N."xsd:string |
| http://purl.uniprot.org/citations/20600640 | http://purl.uniprot.org/core/author | "Sohnchen J."xsd:string |
| http://purl.uniprot.org/citations/20600640 | http://purl.uniprot.org/core/author | "Kaidoglou K."xsd:string |
| http://purl.uniprot.org/citations/20600640 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20600640 | http://purl.uniprot.org/core/name | "Neuroscience"xsd:string |
| http://purl.uniprot.org/citations/20600640 | http://purl.uniprot.org/core/pages | "372-380"xsd:string |
| http://purl.uniprot.org/citations/20600640 | http://purl.uniprot.org/core/title | "Recovery of whisking function after manual stimulation of denervated vibrissal muscles requires brain-derived neurotrophic factor and its receptor tyrosine kinase B."xsd:string |
| http://purl.uniprot.org/citations/20600640 | http://purl.uniprot.org/core/volume | "170"xsd:string |
| http://purl.uniprot.org/citations/20600640 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20600640 |
| http://purl.uniprot.org/citations/20600640 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20600640 |
| http://purl.uniprot.org/uniprot/#_A0A286YCV8-mappedCitation-20600640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20600640 |
| http://purl.uniprot.org/uniprot/#_A0A286YDA0-mappedCitation-20600640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20600640 |
| http://purl.uniprot.org/uniprot/#_A0A286YDA3-mappedCitation-20600640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20600640 |