| http://purl.uniprot.org/citations/20601937 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20601937 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20601937 | http://www.w3.org/2000/01/rdf-schema#comment | "An important facet of transcriptional repression by Polycomb repressive complex 1 (PRC1) is the mono-ubiquitination of histone H2A by the combined action of the Posterior sex combs (Psc) and Sex combs extra (Sce) proteins. Here, we report that two ubiquitin-specific proteases, USP7 and USP11, co-purify with human PRC1-type complexes through direct interactions with the Psc orthologues MEL18 and BMI1, and with other PRC1 components. Ablation of either USP7 or USP11 in primary human fibroblasts results in de-repression of the INK4a tumour suppressor accompanied by loss of PRC1 binding at the locus and a senescence-like proliferative arrest. Mechanistically, USP7 and USP11 regulate the ubiquitination status of the Psc and Sce proteins themselves, thereby affecting their turnover and abundance. Our results point to a novel function for USPs in the regulation and function of Polycomb complexes."xsd:string |
| http://purl.uniprot.org/citations/20601937 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2010.129"xsd:string |
| http://purl.uniprot.org/citations/20601937 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2010.129"xsd:string |
| http://purl.uniprot.org/citations/20601937 | http://purl.uniprot.org/core/author | "Peters G."xsd:string |
| http://purl.uniprot.org/citations/20601937 | http://purl.uniprot.org/core/author | "Peters G."xsd:string |
| http://purl.uniprot.org/citations/20601937 | http://purl.uniprot.org/core/author | "Maertens G.N."xsd:string |
| http://purl.uniprot.org/citations/20601937 | http://purl.uniprot.org/core/author | "Maertens G.N."xsd:string |
| http://purl.uniprot.org/citations/20601937 | http://purl.uniprot.org/core/author | "Hiom K."xsd:string |
| http://purl.uniprot.org/citations/20601937 | http://purl.uniprot.org/core/author | "Hiom K."xsd:string |
| http://purl.uniprot.org/citations/20601937 | http://purl.uniprot.org/core/author | "Elderkin S."xsd:string |
| http://purl.uniprot.org/citations/20601937 | http://purl.uniprot.org/core/author | "Elderkin S."xsd:string |
| http://purl.uniprot.org/citations/20601937 | http://purl.uniprot.org/core/author | "El Messaoudi-Aubert S."xsd:string |
| http://purl.uniprot.org/citations/20601937 | http://purl.uniprot.org/core/author | "El Messaoudi-Aubert S."xsd:string |
| http://purl.uniprot.org/citations/20601937 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20601937 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20601937 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/20601937 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/20601937 | http://purl.uniprot.org/core/pages | "2553-2565"xsd:string |
| http://purl.uniprot.org/citations/20601937 | http://purl.uniprot.org/core/pages | "2553-2565"xsd:string |
| http://purl.uniprot.org/citations/20601937 | http://purl.uniprot.org/core/title | "Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor."xsd:string |
| http://purl.uniprot.org/citations/20601937 | http://purl.uniprot.org/core/title | "Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor."xsd:string |
| http://purl.uniprot.org/citations/20601937 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/20601937 | http://purl.uniprot.org/core/volume | "29"xsd:string |