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| http://purl.uniprot.org/citations/20601947 | http://www.w3.org/2000/01/rdf-schema#comment | "Synapse-to-nucleus signaling is critical for synaptic development and plasticity. In Drosophila, the ligand Wingless causes the C terminus of its Frizzled2 receptor (Fz2-C) to be cleaved and translocated from the postsynaptic density to nuclei. The mechanism of nuclear import is unknown and the developmental consequences of this translocation are uncertain. We found that Fz2-C localization to muscle nuclei required the nuclear import factors Importin-beta11 and Importin-alpha2 and that this pathway promoted the postsynaptic development of the subsynaptic reticulum (SSR), an elaboration of the postsynaptic plasma membrane. importin-beta11 (imp-beta11) and dfz2 mutants had less SSR, and some boutons lacked the postsynaptic marker Discs Large. These developmental defects in imp-beta11 mutants could be overcome by expression of Fz2-C fused to a nuclear localization sequence that can bypass Importin-beta11. Thus, Wnt-activated growth of the postsynaptic membrane is mediated by the synapse-to-nucleus translocation and active nuclear import of Fz2-C via a selective Importin-beta11/alpha2 pathway."xsd:string |
| http://purl.uniprot.org/citations/20601947 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn.2593"xsd:string |
| http://purl.uniprot.org/citations/20601947 | http://purl.uniprot.org/core/author | "Schwarz T.L."xsd:string |
| http://purl.uniprot.org/citations/20601947 | http://purl.uniprot.org/core/author | "Mosca T.J."xsd:string |
| http://purl.uniprot.org/citations/20601947 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20601947 | http://purl.uniprot.org/core/name | "Nat Neurosci"xsd:string |
| http://purl.uniprot.org/citations/20601947 | http://purl.uniprot.org/core/pages | "935-943"xsd:string |
| http://purl.uniprot.org/citations/20601947 | http://purl.uniprot.org/core/title | "The nuclear import of Frizzled2-C by Importins-beta11 and alpha2 promotes postsynaptic development."xsd:string |
| http://purl.uniprot.org/citations/20601947 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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