| http://purl.uniprot.org/citations/20604901 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20604901 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20604901 | http://www.w3.org/2000/01/rdf-schema#comment | "The sorting nexins SNX1 and SNX2 are members of the retromer complex involved in protein sorting within the endocytic pathway. While retromer-dependent functions of SNX1 and SNX2 have been well documented, potential retromer-independent roles remain unclear. Here, we show that SNX1 and SNX2 interact with the Rac1 and RhoG guanine nucleotide exchange factor Kalirin-7. Simultaneous overexpression of SNX1 or SNX2 and Kalirin-7 in epithelial cells causes partial redistribution of both SNX isoforms to the plasma membrane, and results in RhoG-dependent lamellipodia formation that requires functional Phox homology (PX) and Bin/Amphiphysin/Rvs (BAR) domains of SNX, but is Rac1- and retromer-independent. Conversely, depletion of endogenous SNX1 or SNX2 inhibits Kalirin-7-mediated lamellipodia formation. Finally, we demonstrate that SNX1 and SNX2 interact directly with inactive RhoG, suggesting a novel role for these SNX proteins in recruiting an inactive Rho GTPase to its exchange factor."xsd:string |
| http://purl.uniprot.org/citations/20604901 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1600-0854.2010.01100.x"xsd:string |
| http://purl.uniprot.org/citations/20604901 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1600-0854.2010.01100.x"xsd:string |
| http://purl.uniprot.org/citations/20604901 | http://purl.uniprot.org/core/author | "Wendland B."xsd:string |
| http://purl.uniprot.org/citations/20604901 | http://purl.uniprot.org/core/author | "Wendland B."xsd:string |
| http://purl.uniprot.org/citations/20604901 | http://purl.uniprot.org/core/author | "Tran D."xsd:string |
| http://purl.uniprot.org/citations/20604901 | http://purl.uniprot.org/core/author | "Tran D."xsd:string |
| http://purl.uniprot.org/citations/20604901 | http://purl.uniprot.org/core/author | "Ngsee J.K."xsd:string |
| http://purl.uniprot.org/citations/20604901 | http://purl.uniprot.org/core/author | "Ngsee J.K."xsd:string |
| http://purl.uniprot.org/citations/20604901 | http://purl.uniprot.org/core/author | "Prosser D.C."xsd:string |
| http://purl.uniprot.org/citations/20604901 | http://purl.uniprot.org/core/author | "Prosser D.C."xsd:string |
| http://purl.uniprot.org/citations/20604901 | http://purl.uniprot.org/core/author | "Schooley A."xsd:string |
| http://purl.uniprot.org/citations/20604901 | http://purl.uniprot.org/core/author | "Schooley A."xsd:string |
| http://purl.uniprot.org/citations/20604901 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20604901 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20604901 | http://purl.uniprot.org/core/name | "Traffic"xsd:string |
| http://purl.uniprot.org/citations/20604901 | http://purl.uniprot.org/core/name | "Traffic"xsd:string |
| http://purl.uniprot.org/citations/20604901 | http://purl.uniprot.org/core/pages | "1347-1362"xsd:string |
| http://purl.uniprot.org/citations/20604901 | http://purl.uniprot.org/core/pages | "1347-1362"xsd:string |
| http://purl.uniprot.org/citations/20604901 | http://purl.uniprot.org/core/title | "A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling."xsd:string |
| http://purl.uniprot.org/citations/20604901 | http://purl.uniprot.org/core/title | "A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling."xsd:string |
| http://purl.uniprot.org/citations/20604901 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/20604901 | http://purl.uniprot.org/core/volume | "11"xsd:string |