| http://purl.uniprot.org/citations/20605790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20605790 | http://www.w3.org/2000/01/rdf-schema#comment | "Membrane type 1-matrix metalloproteinase (MT1-MMP, MMP14), which is associated with extracellular matrix (ECM) breakdown in squamous cell carcinoma (SCC), promotes tumor formation and epithelial-mesenchymal transition. However, in this report we demonstrate that MT1-MMP, by cleaving the underlying ECM, causes cellular aggregation of keratinocytes and SCC cells. Treatment with an MMP inhibitor abrogated MT1-MMP-induced phenotypic changes, but decreasing E-cadherin expression did not affect MT1-MMP-induced cellular aggregation. As ROCK1/2 can regulate cell-cell and cell-ECM interaction, we examined its role in mediating MT1-MMP-induced phenotypic changes. Blocking ROCK1/2 expression or activity abrogated the cellular aggregation resulting from MT1-MMP expression. Additionally, blocking Rho and non-muscle myosin attenuated MT1-MMP-induced phenotypic changes. Moreover, SCC cells expressing only the catalytically active MT1-MMP protein demonstrated increased cellular aggregation and increased myosin II activity in vivo when injected subcutaneously into nude mice. Together, these results demonstrate that expression of MT1-MMP may be anti-tumorigenic in keratinocytes by promoting cellular aggregation."xsd:string |
| http://purl.uniprot.org/citations/20605790 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.146019"xsd:string |
| http://purl.uniprot.org/citations/20605790 | http://purl.uniprot.org/core/author | "Siddiqui M.A."xsd:string |
| http://purl.uniprot.org/citations/20605790 | http://purl.uniprot.org/core/author | "Redig A.J."xsd:string |
| http://purl.uniprot.org/citations/20605790 | http://purl.uniprot.org/core/author | "Shields M.A."xsd:string |
| http://purl.uniprot.org/citations/20605790 | http://purl.uniprot.org/core/author | "Munshi H.G."xsd:string |
| http://purl.uniprot.org/citations/20605790 | http://purl.uniprot.org/core/author | "Dangi-Garimella S."xsd:string |
| http://purl.uniprot.org/citations/20605790 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20605790 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/20605790 | http://purl.uniprot.org/core/pages | "28363-28372"xsd:string |
| http://purl.uniprot.org/citations/20605790 | http://purl.uniprot.org/core/title | "Rho-ROCK-myosin signaling mediates membrane type 1 matrix metalloproteinase-induced cellular aggregation of keratinocytes."xsd:string |
| http://purl.uniprot.org/citations/20605790 | http://purl.uniprot.org/core/volume | "285"xsd:string |
| http://purl.uniprot.org/citations/20605790 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20605790 |
| http://purl.uniprot.org/citations/20605790 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20605790 |
| http://purl.uniprot.org/uniprot/#_B2R6P3-mappedCitation-20605790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20605790 |
| http://purl.uniprot.org/uniprot/#_K4RH61-mappedCitation-20605790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20605790 |
| http://purl.uniprot.org/uniprot/#_P70336-mappedCitation-20605790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20605790 |
| http://purl.uniprot.org/uniprot/#_F8VPK5-mappedCitation-20605790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20605790 |
| http://purl.uniprot.org/uniprot/#_P50281-mappedCitation-20605790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20605790 |
| http://purl.uniprot.org/uniprot/#_Q3UE22-mappedCitation-20605790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20605790 |
| http://purl.uniprot.org/uniprot/#_Q3UMT5-mappedCitation-20605790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20605790 |
| http://purl.uniprot.org/uniprot/#_P70335-mappedCitation-20605790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20605790 |
| http://purl.uniprot.org/uniprot/#_Q3TBE0-mappedCitation-20605790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20605790 |
| http://purl.uniprot.org/uniprot/#_Q3TR46-mappedCitation-20605790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20605790 |