| http://purl.uniprot.org/citations/20607830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20607830 | http://www.w3.org/2000/01/rdf-schema#comment | "HnRNP G is a member of heterogeneous nuclear ribonucleoprotein (hnRNP) family with potent tumor suppressive activities. Human transformer-2-beta1 (hTra2-beta1) belongs to the arginine-serine rich like proteins and is found over-expressed in various human cancers. It was recently shown that hnRNP G and hTra2-beta1 exert antagonistic effects on alternative splicing. In our study we explored the impact of these two factors in tumor biology of endometrial cancer (EC). EC tissues (n = 139) were tested for hnRNP G and hTra2-beta1 expression on mRNA level by real time PCR and on protein level by immunohistochemistry. HTra2-beta1 mRNA level was found being induced in advanced International Federation of Gynecology and Obstetrics (FIGO) stages (p = 0.016). HnRNP G protein nuclear expression was found more prominent in patients without distant organ metastases (p = 0.033) and in FIGO Stages I/II group (p < 0.001). HTra2-beta1 protein nuclear levels were elevated in poorly differentiated (p = 0.044) and lymph node metastases (p = 0.003) cancers. Kaplan-Meier survival curves revealed that elevated hnRNP G mRNA (p = 0.029) and protein (p = 0.022) levels were associated with a favorable patient outcome. Multivariate Cox-regression analyses identified nuclear hnRNP G level [hazard ratio (HR) 0.468, p = 0.026) as well as hTra2-beta1 level (hazard ratio 5.760, p = 0.004) as independent prognostic factors for EC progression-free survival. Our results indicate that the antagonistic functional effects of hnRNP G and hTra2-beta1 on alternative splicing correlate directly to their opposite clinical effects on EC patient outcome."xsd:string |
| http://purl.uniprot.org/citations/20607830 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.25544"xsd:string |
| http://purl.uniprot.org/citations/20607830 | http://purl.uniprot.org/core/author | "Jager M."xsd:string |
| http://purl.uniprot.org/citations/20607830 | http://purl.uniprot.org/core/author | "zur Hausen A."xsd:string |
| http://purl.uniprot.org/citations/20607830 | http://purl.uniprot.org/core/author | "Tong X.W."xsd:string |
| http://purl.uniprot.org/citations/20607830 | http://purl.uniprot.org/core/author | "Hirschfeld M."xsd:string |
| http://purl.uniprot.org/citations/20607830 | http://purl.uniprot.org/core/author | "Bettendorf H."xsd:string |
| http://purl.uniprot.org/citations/20607830 | http://purl.uniprot.org/core/author | "Orlowska-Volk M."xsd:string |
| http://purl.uniprot.org/citations/20607830 | http://purl.uniprot.org/core/author | "Stickeler E."xsd:string |
| http://purl.uniprot.org/citations/20607830 | http://purl.uniprot.org/core/author | "Ouyang Y.Q."xsd:string |
| http://purl.uniprot.org/citations/20607830 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/20607830 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/20607830 | http://purl.uniprot.org/core/pages | "2010-2019"xsd:string |
| http://purl.uniprot.org/citations/20607830 | http://purl.uniprot.org/core/title | "Expression levels of hnRNP G and hTra2-beta1 correlate with opposite outcomes in endometrial cancer biology."xsd:string |
| http://purl.uniprot.org/citations/20607830 | http://purl.uniprot.org/core/volume | "128"xsd:string |
| http://purl.uniprot.org/citations/20607830 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20607830 |
| http://purl.uniprot.org/citations/20607830 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20607830 |
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| http://purl.uniprot.org/uniprot/#_A8K8A6-mappedCitation-20607830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20607830 |
| http://purl.uniprot.org/uniprot/#_O75526-mappedCitation-20607830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20607830 |
| http://purl.uniprot.org/uniprot/#_P62995-mappedCitation-20607830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20607830 |
| http://purl.uniprot.org/uniprot/#_Q68DZ9-mappedCitation-20607830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20607830 |
| http://purl.uniprot.org/uniprot/#_Q59GA1-mappedCitation-20607830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20607830 |
| http://purl.uniprot.org/uniprot/#_Q8N1H4-mappedCitation-20607830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20607830 |