| http://purl.uniprot.org/citations/20610891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20610891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20610891 | http://www.w3.org/2000/01/rdf-schema#comment | "Human organic anion transporter OATP4C1 is a member of the OATP family predominantly expressed in the kidney, and contributes to the renal secretion of digoxin. However, little is known about the characteristics of OATP4C1-madiated transport. We examined the transport of estrone 3-sulfate, which is known as a substrate for other OATPs, by OATP4C1-expressing cells. Estrone 3-sulfate was efficiently transported by OATP4C1. The Michaelis-Menten constant for estrone 3-sulfate uptake by OATP4C1 was 26.6+/-4.9 microM. Transport of estrone 3-sulfate was significantly inhibited by triiodothyronine, chenodeoxycholic acid, bromosulfophtalein, and cyclosporine, whereas known substrates of OATP4C1, digoxin and ouabain, did not change OATP4C1-mediated transport. We further examined the mutual inhibition study between estrone 3-sulfate and digoxin. Digoxin partially inhibited the estrone 3-sulfate transport, and estrone 3-sulfate did not significantly inhibit digoxin transport. The estimated IC(50) value of digoxin for OATP4C1-mediated estrone 3-sulfate transport was 119 microM. This value is not comparable with the Michaelis-Menten constant for digoxin uptake by OATP4C1 (7.8 microM) reported by Mikkaichi et al.(1)) In conclusion, we found that estrone 3-sulfate is a novel substrate for OATP4C1. Moreover, our results indicate that estrone 3-sulfate does not bind to the recognition site for digoxin in OATP4C1."xsd:string |
| http://purl.uniprot.org/citations/20610891 | http://purl.org/dc/terms/identifier | "doi:10.2133/dmpk.25.314"xsd:string |
| http://purl.uniprot.org/citations/20610891 | http://purl.org/dc/terms/identifier | "doi:10.2133/dmpk.25.314"xsd:string |
| http://purl.uniprot.org/citations/20610891 | http://purl.uniprot.org/core/author | "Abe T."xsd:string |
| http://purl.uniprot.org/citations/20610891 | http://purl.uniprot.org/core/author | "Abe T."xsd:string |
| http://purl.uniprot.org/citations/20610891 | http://purl.uniprot.org/core/author | "Okada M."xsd:string |
| http://purl.uniprot.org/citations/20610891 | http://purl.uniprot.org/core/author | "Okada M."xsd:string |
| http://purl.uniprot.org/citations/20610891 | http://purl.uniprot.org/core/author | "Yamaguchi H."xsd:string |
| http://purl.uniprot.org/citations/20610891 | http://purl.uniprot.org/core/author | "Yamaguchi H."xsd:string |
| http://purl.uniprot.org/citations/20610891 | http://purl.uniprot.org/core/author | "Shimada M."xsd:string |
| http://purl.uniprot.org/citations/20610891 | http://purl.uniprot.org/core/author | "Shimada M."xsd:string |
| http://purl.uniprot.org/citations/20610891 | http://purl.uniprot.org/core/author | "Goto J."xsd:string |
| http://purl.uniprot.org/citations/20610891 | http://purl.uniprot.org/core/author | "Goto J."xsd:string |
| http://purl.uniprot.org/citations/20610891 | http://purl.uniprot.org/core/author | "Mano N."xsd:string |
| http://purl.uniprot.org/citations/20610891 | http://purl.uniprot.org/core/author | "Mano N."xsd:string |
| http://purl.uniprot.org/citations/20610891 | http://purl.uniprot.org/core/author | "Toyohara T."xsd:string |
| http://purl.uniprot.org/citations/20610891 | http://purl.uniprot.org/core/author | "Toyohara T."xsd:string |
| http://purl.uniprot.org/citations/20610891 | http://purl.uniprot.org/core/author | "Hishinuma T."xsd:string |
| http://purl.uniprot.org/citations/20610891 | http://purl.uniprot.org/core/author | "Hishinuma T."xsd:string |
| http://purl.uniprot.org/citations/20610891 | http://purl.uniprot.org/core/author | "Mikkaichi T."xsd:string |
| http://purl.uniprot.org/citations/20610891 | http://purl.uniprot.org/core/author | "Mikkaichi T."xsd:string |
| http://purl.uniprot.org/citations/20610891 | http://purl.uniprot.org/core/author | "Sugie M."xsd:string |
| http://purl.uniprot.org/citations/20610891 | http://purl.uniprot.org/core/author | "Sugie M."xsd:string |