| http://purl.uniprot.org/citations/20616007 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20616007 | http://www.w3.org/2000/01/rdf-schema#comment | "The neighbor of Brca1 gene (Nbr1) functions as an autophagy receptor involved in targeting ubiquitinated proteins for degradation. It also has a dual role as a scaffold protein to regulate growth-factor receptor and downstream signaling pathways. We show that genetic truncation of murine Nbr1 leads to an age-dependent increase in bone mass and bone mineral density through increased osteoblast differentiation and activity. At 6 mo of age, despite normal body size, homozygous mutant animals (Nbr1(tr/tr)) have approximately 50% more bone than littermate controls. Truncated Nbr1 (trNbr1) co-localizes with p62, a structurally similar interacting scaffold protein, and the autophagosome marker LC3 in osteoblasts, but unlike the full-length protein, trNbr1 fails to complex with activated p38 MAPK. Nbr1(tr/tr) osteoblasts and osteoclasts show increased activation of p38 MAPK, and significantly, pharmacological inhibition of the p38 MAPK pathway in vitro abrogates the increased osteoblast differentiation of Nbr1(tr/tr) cells. Nbr1 truncation also leads to increased p62 protein expression. We show a role for Nbr1 in bone remodeling, where loss of function leads to perturbation of p62 levels and hyperactivation of p38 MAPK that favors osteoblastogenesis."xsd:string |
| http://purl.uniprot.org/citations/20616007 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0913058107"xsd:string |
| http://purl.uniprot.org/citations/20616007 | http://purl.uniprot.org/core/author | "Whitehouse C.A."xsd:string |
| http://purl.uniprot.org/citations/20616007 | http://purl.uniprot.org/core/author | "Solomon E."xsd:string |
| http://purl.uniprot.org/citations/20616007 | http://purl.uniprot.org/core/author | "Sharpe P.T."xsd:string |
| http://purl.uniprot.org/citations/20616007 | http://purl.uniprot.org/core/author | "Waters S."xsd:string |
| http://purl.uniprot.org/citations/20616007 | http://purl.uniprot.org/core/author | "Horner A."xsd:string |
| http://purl.uniprot.org/citations/20616007 | http://purl.uniprot.org/core/author | "Skerry T.M."xsd:string |
| http://purl.uniprot.org/citations/20616007 | http://purl.uniprot.org/core/author | "Marchbank K."xsd:string |
| http://purl.uniprot.org/citations/20616007 | http://purl.uniprot.org/core/author | "Cobourne M.T."xsd:string |
| http://purl.uniprot.org/citations/20616007 | http://purl.uniprot.org/core/author | "Xavier G.M."xsd:string |
| http://purl.uniprot.org/citations/20616007 | http://purl.uniprot.org/core/author | "McGowan N.W."xsd:string |
| http://purl.uniprot.org/citations/20616007 | http://purl.uniprot.org/core/author | "Grigoriadis A.E."xsd:string |
| http://purl.uniprot.org/citations/20616007 | http://purl.uniprot.org/core/author | "Jovanovic J.V."xsd:string |
| http://purl.uniprot.org/citations/20616007 | http://purl.uniprot.org/core/author | "Kashima T.G."xsd:string |
| http://purl.uniprot.org/citations/20616007 | http://purl.uniprot.org/core/author | "Richards G.O."xsd:string |
| http://purl.uniprot.org/citations/20616007 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20616007 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/20616007 | http://purl.uniprot.org/core/pages | "12913-12918"xsd:string |
| http://purl.uniprot.org/citations/20616007 | http://purl.uniprot.org/core/title | "Neighbor of Brca1 gene (Nbr1) functions as a negative regulator of postnatal osteoblastic bone formation and p38 MAPK activity."xsd:string |
| http://purl.uniprot.org/citations/20616007 | http://purl.uniprot.org/core/volume | "107"xsd:string |
| http://purl.uniprot.org/citations/20616007 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20616007 |
| http://purl.uniprot.org/citations/20616007 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20616007 |
| http://purl.uniprot.org/uniprot/P97432#attribution-7051DF7D9B89565FD47C27A15FE66581 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20616007 |