| http://purl.uniprot.org/citations/20616094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20616094 | http://www.w3.org/2000/01/rdf-schema#comment | "Diabetes is characterized by the loss, or gradual dysfunction, of insulin-producing pancreatic beta-cells. Although beta-cells can replicate in younger adults, the available diabetes therapies do not specifically target beta-cell regeneration. Novel approaches are needed to discover new therapeutics and to understand the contributions of endocrine progenitors and beta-cell regeneration during islet expansion. Here, we show that the regulators of G protein signaling Rgs16 and Rgs8 are expressed in pancreatic progenitor and endocrine cells during development, then extinguished in adults, but reactivated in models of both type 1 and type 2 diabetes. Exendin-4, a glucagon-like peptide 1 (Glp-1)/incretin mimetic that stimulates beta-cell expansion, insulin secretion and normalization of blood glucose levels in diabetics, also promoted re-expression of Rgs16::GFP within a few days in pancreatic ductal-associated cells and islet beta-cells. These findings show that Rgs16::GFP and Rgs8::GFP are novel and early reporters of G protein-coupled receptor (GPCR)-stimulated beta-cell expansion after therapeutic treatment and in diabetes models. Rgs16 and Rgs8 are likely to control aspects of islet progenitor cell activation, differentiation and beta-cell expansion in embryos and metabolically stressed adults."xsd:string |
| http://purl.uniprot.org/citations/20616094 | http://purl.org/dc/terms/identifier | "doi:10.1242/dmm.003210"xsd:string |
| http://purl.uniprot.org/citations/20616094 | http://purl.uniprot.org/core/author | "Wilkie T.M."xsd:string |
| http://purl.uniprot.org/citations/20616094 | http://purl.uniprot.org/core/author | "Scherer P.E."xsd:string |
| http://purl.uniprot.org/citations/20616094 | http://purl.uniprot.org/core/author | "Cleaver O."xsd:string |
| http://purl.uniprot.org/citations/20616094 | http://purl.uniprot.org/core/author | "Wang Z.V."xsd:string |
| http://purl.uniprot.org/citations/20616094 | http://purl.uniprot.org/core/author | "Villasenor A."xsd:string |
| http://purl.uniprot.org/citations/20616094 | http://purl.uniprot.org/core/author | "Brekken R.A."xsd:string |
| http://purl.uniprot.org/citations/20616094 | http://purl.uniprot.org/core/author | "Rivera L.B."xsd:string |
| http://purl.uniprot.org/citations/20616094 | http://purl.uniprot.org/core/author | "Asterholm I.W."xsd:string |
| http://purl.uniprot.org/citations/20616094 | http://purl.uniprot.org/core/author | "Ocal O."xsd:string |
| http://purl.uniprot.org/citations/20616094 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20616094 | http://purl.uniprot.org/core/name | "Dis Model Mech"xsd:string |
| http://purl.uniprot.org/citations/20616094 | http://purl.uniprot.org/core/pages | "567-580"xsd:string |
| http://purl.uniprot.org/citations/20616094 | http://purl.uniprot.org/core/title | "Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of diabetes."xsd:string |
| http://purl.uniprot.org/citations/20616094 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/20616094 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20616094 |
| http://purl.uniprot.org/citations/20616094 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20616094 |
| http://purl.uniprot.org/uniprot/#_A0A087WPW1-mappedCitation-20616094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20616094 |
| http://purl.uniprot.org/uniprot/#_A0A087WQG6-mappedCitation-20616094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20616094 |
| http://purl.uniprot.org/uniprot/#_A0A087WNZ9-mappedCitation-20616094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20616094 |
| http://purl.uniprot.org/uniprot/#_A0A087WPC4-mappedCitation-20616094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20616094 |
| http://purl.uniprot.org/uniprot/#_A0A087WPD1-mappedCitation-20616094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20616094 |
| http://purl.uniprot.org/uniprot/#_A0A087WSH2-mappedCitation-20616094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20616094 |